Morphological evidence for calcium-dependent association of calgranulin with the epidermal cytoskeleton in inflammatory dermatoses

Susan E. Kelly, J.A.A. Hunter, D. B. Jones, B.R. Clark, S. Fleming

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    15 Citations (Scopus)

    Abstract

    The association of calgranulins, intracellular calcium-binding proteins, with the keratinocyte cytoskeleton has been studied. These molecules are expressed in various inflammatory dermatoses and in organ-culture explants. Triton X-100 extraction in the presence of calcium or EDTA suggested that calgranulins are detergent insoluble in the presence of calcium. The molecules were localized in a plaque-like structure at the cell periphery in lesional skin and in organ-culture explants. Following induction of calgranulins in vitro there was a redistribution of the intermediate filament cytoskeleton into a perinuclear halo, although desmosomes remained intact. These various features suggest that these members of the S-100 protein family have a role in cytoskeletal changes seen in various skin diseases.
    Original languageEnglish
    Pages (from-to)403-9
    Number of pages7
    JournalBritish Journal of Dermatology
    Volume124
    Issue number5
    DOIs
    Publication statusPublished - 1991

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