Morphometric pattern analysis of basal cell nuclei for oral cancer screening

P. Shah, M. Muthu Rama Krishnan, C. Chakraborty, A. Kumar Ray

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

This work presents a quantitative approach for discrimination of Oral Submucous Fibrosis (OSF) to Normal Oral Mucosa (NOM) in respect to size and shape properties of the basal layer, first layer in epithelium. Practically, basal cells form the proliferative compartment of the epithelium, and therefore changes in the morphometry of basal cells may have serious implications on future cell behavior, including malignant transformation according to onco-pathologists vision. In view of this, the changes in shape and size of the nuclei in the basal cell layer of the oral epithelium have been studied here by developing an automated image analyzer. Geometric, Zernike moments and transformation based features are extracted for morphometric pattern analysis of the nuclei. These features are statistically analyzed along with 3D visualization in order to discriminate the groups. Results showed increase in the dimensions (area and perimeter) and shape parameters of the nuclei from normal mucosa to OSF with dysplasia. Finally, pattern analyzer is employed using Bayesian approach and error back-propagation neural network. The performance is evaluated by partitioning the whole data set into various combinations of training-testing subsets, finally which converge to overall accuracies 97.02% for neural network and 97.93% for Bayesian classifier respectively.
Original languageEnglish
Title of host publication2010 4th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2010
PublisherIEEE
Number of pages4
ISBN (Print)9781424447121
DOIs
Publication statusPublished - 2010
Event4th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2010 - Chengdu, China
Duration: 18 Jun 201020 Jun 2010
https://ieeexplore.ieee.org/xpl/conhome/5513048/proceeding

Conference

Conference4th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2010
CountryChina
CityChengdu
Period18/06/1020/06/10
Internet address

Keywords

  • Pattern analysis
  • Cancer
  • Diseases
  • Image analysis
  • Feature extraction
  • Shape measurement
  • Bayesian methods
  • Neural networks
  • Lesions
  • Biopsy

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    Shah, P., Muthu Rama Krishnan, M., Chakraborty, C., & Kumar Ray, A. (2010). Morphometric pattern analysis of basal cell nuclei for oral cancer screening. In 2010 4th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2010 IEEE. https://doi.org/10.1109/ICBBE.2010.5517397