Mortality in schizophrenia and other psychoses: a 10-year follow-up of the ӔSOP first-episode cohort

Ulrich Reininghaus (Lead / Corresponding author), Rina Dutta, Paola Dazzan, Gillian A. Doody, Paul Fearon, Julia Lappin, Margaret Heslin, Adanna Onyejiaka, Kim Donoghue, Ben Lomas, James B. Kirkbride, Robin M. Murray, Tim Croudace, Craig Morgan, Peter B. Jones

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The excess mortality in people with psychotic disorders is a major public health concern, but little is known about the clinical and social risk factors which may predict this health inequality and help inform preventative strategies. We aimed to investigate mortality in a large epidemiologically characterized cohort of individuals with first-episode psychosis compared with the general population and to determine clinical and social risk factors for premature death. All 557 individuals with first-episode psychosis initially identified in 2 areas (Southeast London and Nottinghamshire, United Kingdom) were traced over a 10-year period in the ӔSOP-10 study. Compared with the general population, all-cause (standardized mortality ratio [SMR] 3.6, 95% confidence interval [CI] 2.6-4.9), natural-cause (SMR 1.7, 95% CI 1.0-2.7) and unnatural-cause (SMR 13.3, 95% CI 8.7-20.4) mortality was very high. Illicit drug use was associated with an increased risk of all-cause mortality (adj. rate ratio [RR] 2.31, 95% CI 1.06-5.03). Risk of natural-cause mortality increased with a longer time to first remission (adj. RR 6.61, 95% CI 1.33-32.77). Family involvement at first contact strongly reduced risk of unnatural-cause mortality (adj. RR 0.09, 95% CI 0.01-0.69). Our findings suggest that the mortality gap in people with psychotic disorders remains huge and may be wider for unnatural-cause mortality than previously reported. Efforts should now focus on further understanding and targeting these tractable clinical and social risk factors of excess mortality. Early intervention and dual diagnosis services may play a key role in achieving more rapid remission and carer involvement and addressing substance use problems to reduce excess mortality in psychosis.

Original languageEnglish
Pages (from-to)664-673
Number of pages10
JournalSchizophrenia Bulletin
Volume41
Issue number3
Early online date27 Sep 2014
DOIs
Publication statusPublished - May 2015

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Psychotic Disorders
Schizophrenia
Mortality
Confidence Intervals
Dual (Psychiatry) Diagnosis
Premature Mortality
Street Drugs
Caregivers
Population
Early Diagnosis
Public Health

Keywords

  • Schizophrenia
  • Mortality
  • Psychosis
  • Risk factors

Cite this

Reininghaus, U., Dutta, R., Dazzan, P., Doody, G. A., Fearon, P., Lappin, J., ... Jones, P. B. (2015). Mortality in schizophrenia and other psychoses: a 10-year follow-up of the ӔSOP first-episode cohort. Schizophrenia Bulletin, 41(3), 664-673. https://doi.org/10.1093/schbul/sbu138
Reininghaus, Ulrich ; Dutta, Rina ; Dazzan, Paola ; Doody, Gillian A. ; Fearon, Paul ; Lappin, Julia ; Heslin, Margaret ; Onyejiaka, Adanna ; Donoghue, Kim ; Lomas, Ben ; Kirkbride, James B. ; Murray, Robin M. ; Croudace, Tim ; Morgan, Craig ; Jones, Peter B. / Mortality in schizophrenia and other psychoses : a 10-year follow-up of the ӔSOP first-episode cohort. In: Schizophrenia Bulletin. 2015 ; Vol. 41, No. 3. pp. 664-673.
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abstract = "The excess mortality in people with psychotic disorders is a major public health concern, but little is known about the clinical and social risk factors which may predict this health inequality and help inform preventative strategies. We aimed to investigate mortality in a large epidemiologically characterized cohort of individuals with first-episode psychosis compared with the general population and to determine clinical and social risk factors for premature death. All 557 individuals with first-episode psychosis initially identified in 2 areas (Southeast London and Nottinghamshire, United Kingdom) were traced over a 10-year period in the ӔSOP-10 study. Compared with the general population, all-cause (standardized mortality ratio [SMR] 3.6, 95{\%} confidence interval [CI] 2.6-4.9), natural-cause (SMR 1.7, 95{\%} CI 1.0-2.7) and unnatural-cause (SMR 13.3, 95{\%} CI 8.7-20.4) mortality was very high. Illicit drug use was associated with an increased risk of all-cause mortality (adj. rate ratio [RR] 2.31, 95{\%} CI 1.06-5.03). Risk of natural-cause mortality increased with a longer time to first remission (adj. RR 6.61, 95{\%} CI 1.33-32.77). Family involvement at first contact strongly reduced risk of unnatural-cause mortality (adj. RR 0.09, 95{\%} CI 0.01-0.69). Our findings suggest that the mortality gap in people with psychotic disorders remains huge and may be wider for unnatural-cause mortality than previously reported. Efforts should now focus on further understanding and targeting these tractable clinical and social risk factors of excess mortality. Early intervention and dual diagnosis services may play a key role in achieving more rapid remission and carer involvement and addressing substance use problems to reduce excess mortality in psychosis.",
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Reininghaus, U, Dutta, R, Dazzan, P, Doody, GA, Fearon, P, Lappin, J, Heslin, M, Onyejiaka, A, Donoghue, K, Lomas, B, Kirkbride, JB, Murray, RM, Croudace, T, Morgan, C & Jones, PB 2015, 'Mortality in schizophrenia and other psychoses: a 10-year follow-up of the ӔSOP first-episode cohort', Schizophrenia Bulletin, vol. 41, no. 3, pp. 664-673. https://doi.org/10.1093/schbul/sbu138

Mortality in schizophrenia and other psychoses : a 10-year follow-up of the ӔSOP first-episode cohort. / Reininghaus, Ulrich (Lead / Corresponding author); Dutta, Rina; Dazzan, Paola; Doody, Gillian A.; Fearon, Paul; Lappin, Julia; Heslin, Margaret; Onyejiaka, Adanna; Donoghue, Kim; Lomas, Ben; Kirkbride, James B.; Murray, Robin M.; Croudace, Tim; Morgan, Craig; Jones, Peter B.

In: Schizophrenia Bulletin, Vol. 41, No. 3, 05.2015, p. 664-673.

Research output: Contribution to journalArticle

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T1 - Mortality in schizophrenia and other psychoses

T2 - a 10-year follow-up of the ӔSOP first-episode cohort

AU - Reininghaus, Ulrich

AU - Dutta, Rina

AU - Dazzan, Paola

AU - Doody, Gillian A.

AU - Fearon, Paul

AU - Lappin, Julia

AU - Heslin, Margaret

AU - Onyejiaka, Adanna

AU - Donoghue, Kim

AU - Lomas, Ben

AU - Kirkbride, James B.

AU - Murray, Robin M.

AU - Croudace, Tim

AU - Morgan, Craig

AU - Jones, Peter B.

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N2 - The excess mortality in people with psychotic disorders is a major public health concern, but little is known about the clinical and social risk factors which may predict this health inequality and help inform preventative strategies. We aimed to investigate mortality in a large epidemiologically characterized cohort of individuals with first-episode psychosis compared with the general population and to determine clinical and social risk factors for premature death. All 557 individuals with first-episode psychosis initially identified in 2 areas (Southeast London and Nottinghamshire, United Kingdom) were traced over a 10-year period in the ӔSOP-10 study. Compared with the general population, all-cause (standardized mortality ratio [SMR] 3.6, 95% confidence interval [CI] 2.6-4.9), natural-cause (SMR 1.7, 95% CI 1.0-2.7) and unnatural-cause (SMR 13.3, 95% CI 8.7-20.4) mortality was very high. Illicit drug use was associated with an increased risk of all-cause mortality (adj. rate ratio [RR] 2.31, 95% CI 1.06-5.03). Risk of natural-cause mortality increased with a longer time to first remission (adj. RR 6.61, 95% CI 1.33-32.77). Family involvement at first contact strongly reduced risk of unnatural-cause mortality (adj. RR 0.09, 95% CI 0.01-0.69). Our findings suggest that the mortality gap in people with psychotic disorders remains huge and may be wider for unnatural-cause mortality than previously reported. Efforts should now focus on further understanding and targeting these tractable clinical and social risk factors of excess mortality. Early intervention and dual diagnosis services may play a key role in achieving more rapid remission and carer involvement and addressing substance use problems to reduce excess mortality in psychosis.

AB - The excess mortality in people with psychotic disorders is a major public health concern, but little is known about the clinical and social risk factors which may predict this health inequality and help inform preventative strategies. We aimed to investigate mortality in a large epidemiologically characterized cohort of individuals with first-episode psychosis compared with the general population and to determine clinical and social risk factors for premature death. All 557 individuals with first-episode psychosis initially identified in 2 areas (Southeast London and Nottinghamshire, United Kingdom) were traced over a 10-year period in the ӔSOP-10 study. Compared with the general population, all-cause (standardized mortality ratio [SMR] 3.6, 95% confidence interval [CI] 2.6-4.9), natural-cause (SMR 1.7, 95% CI 1.0-2.7) and unnatural-cause (SMR 13.3, 95% CI 8.7-20.4) mortality was very high. Illicit drug use was associated with an increased risk of all-cause mortality (adj. rate ratio [RR] 2.31, 95% CI 1.06-5.03). Risk of natural-cause mortality increased with a longer time to first remission (adj. RR 6.61, 95% CI 1.33-32.77). Family involvement at first contact strongly reduced risk of unnatural-cause mortality (adj. RR 0.09, 95% CI 0.01-0.69). Our findings suggest that the mortality gap in people with psychotic disorders remains huge and may be wider for unnatural-cause mortality than previously reported. Efforts should now focus on further understanding and targeting these tractable clinical and social risk factors of excess mortality. Early intervention and dual diagnosis services may play a key role in achieving more rapid remission and carer involvement and addressing substance use problems to reduce excess mortality in psychosis.

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KW - Mortality

KW - Psychosis

KW - Risk factors

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DO - 10.1093/schbul/sbu138

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