MRI comparison of quantitative left ventricular structure, function and measurement reproducibility in patient cohorts with a range of clinically distinct cardiac conditions

Stephen J. Gandy, Shelley A. Waugh, R. Stephen Nicholas, Narasimharaj Rajendra, Patricia Martin, J. Graeme Houston

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    Aim Quantitative MRI assessments of cardiac structure and function are possible and potentially useful for longitudinal clinical monitoring. The aim of this study was to compare the magnitude and repeatability of left ventricular (LV) ejection fraction (EF) and mass (LVM) measurements in patients with clinically distinct cardiac conditions. Materials and Methods Patients were recruited into four groups: (i) congestive heart failure (CHF), (ii) left ventricular hypertrophy (LVH), (iii) recent post myocardial infarct (PMI), and (iv) healthy normal volunteers (HNV). LV short-axis images were acquired on a 1.5T MRI scanner and analysed on a satellite workstation. EF and LVM (at ED) values were derived from myocardial segmentations, and intra- observer test-retest coefficients of repeatability (CoR) were determined for each cohort. Results The mean EF for the CHF patients (30.3%) was lower than for the other cohorts (LVH 72.7%, PMI 53.0%, HNV 67.0%; P < 0.0002). As expected, the mean LVM for the CHF patients (143 g) was greater than for the other cohorts (LVH 122 g, PMI 124 g, HNV 107 g), but only significant when compared to the HNV cohort (P = 0.004). The intra-observer CoR values for EF were 1.5% (LVH), 1.6% (HNV), 2.6% (PMI) and 5.5% (CHF), and 4.6 g (HNV), 6.7 g (PMI), 8.3 g (CHF) and 9.8 g (LVH) for LVM. Conclusion The EF, LVM and associated repeatability parameters are variable and dependent upon the clinical condition under investigation. It is important that reproducibility data for EF and LVM are acquired individually and specifically on a per-cohort basis if the parameters are to form reliable endpoints for longitudinal clinical follow-up assessments.

    Original languageEnglish
    Pages (from-to)627-632
    Number of pages6
    JournalInternational Journal of Cardiovascular Imaging
    Volume24
    Issue number6
    DOIs
    Publication statusPublished - Aug 2008

    Keywords

    • magnetic resonance imaging
    • left ventricular ejection fraction
    • left ventricular mass
    • repeatability
    • patient volunteers
    • CARDIOVASCULAR MAGNETIC-RESONANCE
    • HEART-FAILURE
    • INTERSTUDY REPRODUCIBILITY
    • MASS
    • ECHOCARDIOGRAPHY
    • PARAMETERS
    • DIMENSIONS
    • REDUCTION
    • SIZE
    • CMR

    Cite this

    @article{2d8dda78ddad48039c32fdf2fbbc7ccd,
    title = "MRI comparison of quantitative left ventricular structure, function and measurement reproducibility in patient cohorts with a range of clinically distinct cardiac conditions",
    abstract = "Aim Quantitative MRI assessments of cardiac structure and function are possible and potentially useful for longitudinal clinical monitoring. The aim of this study was to compare the magnitude and repeatability of left ventricular (LV) ejection fraction (EF) and mass (LVM) measurements in patients with clinically distinct cardiac conditions. Materials and Methods Patients were recruited into four groups: (i) congestive heart failure (CHF), (ii) left ventricular hypertrophy (LVH), (iii) recent post myocardial infarct (PMI), and (iv) healthy normal volunteers (HNV). LV short-axis images were acquired on a 1.5T MRI scanner and analysed on a satellite workstation. EF and LVM (at ED) values were derived from myocardial segmentations, and intra- observer test-retest coefficients of repeatability (CoR) were determined for each cohort. Results The mean EF for the CHF patients (30.3{\%}) was lower than for the other cohorts (LVH 72.7{\%}, PMI 53.0{\%}, HNV 67.0{\%}; P < 0.0002). As expected, the mean LVM for the CHF patients (143 g) was greater than for the other cohorts (LVH 122 g, PMI 124 g, HNV 107 g), but only significant when compared to the HNV cohort (P = 0.004). The intra-observer CoR values for EF were 1.5{\%} (LVH), 1.6{\%} (HNV), 2.6{\%} (PMI) and 5.5{\%} (CHF), and 4.6 g (HNV), 6.7 g (PMI), 8.3 g (CHF) and 9.8 g (LVH) for LVM. Conclusion The EF, LVM and associated repeatability parameters are variable and dependent upon the clinical condition under investigation. It is important that reproducibility data for EF and LVM are acquired individually and specifically on a per-cohort basis if the parameters are to form reliable endpoints for longitudinal clinical follow-up assessments.",
    keywords = "magnetic resonance imaging, left ventricular ejection fraction, left ventricular mass, repeatability, patient volunteers, CARDIOVASCULAR MAGNETIC-RESONANCE, HEART-FAILURE, INTERSTUDY REPRODUCIBILITY, MASS, ECHOCARDIOGRAPHY, PARAMETERS, DIMENSIONS, REDUCTION, SIZE, CMR",
    author = "Gandy, {Stephen J.} and Waugh, {Shelley A.} and Nicholas, {R. Stephen} and Narasimharaj Rajendra and Patricia Martin and Houston, {J. Graeme}",
    year = "2008",
    month = "8",
    doi = "10.1007/s10554-008-9293-5",
    language = "English",
    volume = "24",
    pages = "627--632",
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    }

    MRI comparison of quantitative left ventricular structure, function and measurement reproducibility in patient cohorts with a range of clinically distinct cardiac conditions. / Gandy, Stephen J.; Waugh, Shelley A.; Nicholas, R. Stephen; Rajendra, Narasimharaj; Martin, Patricia; Houston, J. Graeme.

    In: International Journal of Cardiovascular Imaging, Vol. 24, No. 6, 08.2008, p. 627-632.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - MRI comparison of quantitative left ventricular structure, function and measurement reproducibility in patient cohorts with a range of clinically distinct cardiac conditions

    AU - Gandy, Stephen J.

    AU - Waugh, Shelley A.

    AU - Nicholas, R. Stephen

    AU - Rajendra, Narasimharaj

    AU - Martin, Patricia

    AU - Houston, J. Graeme

    PY - 2008/8

    Y1 - 2008/8

    N2 - Aim Quantitative MRI assessments of cardiac structure and function are possible and potentially useful for longitudinal clinical monitoring. The aim of this study was to compare the magnitude and repeatability of left ventricular (LV) ejection fraction (EF) and mass (LVM) measurements in patients with clinically distinct cardiac conditions. Materials and Methods Patients were recruited into four groups: (i) congestive heart failure (CHF), (ii) left ventricular hypertrophy (LVH), (iii) recent post myocardial infarct (PMI), and (iv) healthy normal volunteers (HNV). LV short-axis images were acquired on a 1.5T MRI scanner and analysed on a satellite workstation. EF and LVM (at ED) values were derived from myocardial segmentations, and intra- observer test-retest coefficients of repeatability (CoR) were determined for each cohort. Results The mean EF for the CHF patients (30.3%) was lower than for the other cohorts (LVH 72.7%, PMI 53.0%, HNV 67.0%; P < 0.0002). As expected, the mean LVM for the CHF patients (143 g) was greater than for the other cohorts (LVH 122 g, PMI 124 g, HNV 107 g), but only significant when compared to the HNV cohort (P = 0.004). The intra-observer CoR values for EF were 1.5% (LVH), 1.6% (HNV), 2.6% (PMI) and 5.5% (CHF), and 4.6 g (HNV), 6.7 g (PMI), 8.3 g (CHF) and 9.8 g (LVH) for LVM. Conclusion The EF, LVM and associated repeatability parameters are variable and dependent upon the clinical condition under investigation. It is important that reproducibility data for EF and LVM are acquired individually and specifically on a per-cohort basis if the parameters are to form reliable endpoints for longitudinal clinical follow-up assessments.

    AB - Aim Quantitative MRI assessments of cardiac structure and function are possible and potentially useful for longitudinal clinical monitoring. The aim of this study was to compare the magnitude and repeatability of left ventricular (LV) ejection fraction (EF) and mass (LVM) measurements in patients with clinically distinct cardiac conditions. Materials and Methods Patients were recruited into four groups: (i) congestive heart failure (CHF), (ii) left ventricular hypertrophy (LVH), (iii) recent post myocardial infarct (PMI), and (iv) healthy normal volunteers (HNV). LV short-axis images were acquired on a 1.5T MRI scanner and analysed on a satellite workstation. EF and LVM (at ED) values were derived from myocardial segmentations, and intra- observer test-retest coefficients of repeatability (CoR) were determined for each cohort. Results The mean EF for the CHF patients (30.3%) was lower than for the other cohorts (LVH 72.7%, PMI 53.0%, HNV 67.0%; P < 0.0002). As expected, the mean LVM for the CHF patients (143 g) was greater than for the other cohorts (LVH 122 g, PMI 124 g, HNV 107 g), but only significant when compared to the HNV cohort (P = 0.004). The intra-observer CoR values for EF were 1.5% (LVH), 1.6% (HNV), 2.6% (PMI) and 5.5% (CHF), and 4.6 g (HNV), 6.7 g (PMI), 8.3 g (CHF) and 9.8 g (LVH) for LVM. Conclusion The EF, LVM and associated repeatability parameters are variable and dependent upon the clinical condition under investigation. It is important that reproducibility data for EF and LVM are acquired individually and specifically on a per-cohort basis if the parameters are to form reliable endpoints for longitudinal clinical follow-up assessments.

    KW - magnetic resonance imaging

    KW - left ventricular ejection fraction

    KW - left ventricular mass

    KW - repeatability

    KW - patient volunteers

    KW - CARDIOVASCULAR MAGNETIC-RESONANCE

    KW - HEART-FAILURE

    KW - INTERSTUDY REPRODUCIBILITY

    KW - MASS

    KW - ECHOCARDIOGRAPHY

    KW - PARAMETERS

    KW - DIMENSIONS

    KW - REDUCTION

    KW - SIZE

    KW - CMR

    U2 - 10.1007/s10554-008-9293-5

    DO - 10.1007/s10554-008-9293-5

    M3 - Article

    VL - 24

    SP - 627

    EP - 632

    JO - International Journal of Cardiovascular Imaging

    JF - International Journal of Cardiovascular Imaging

    SN - 1569-5794

    IS - 6

    ER -