Projects per year
Abstract
In this review we explore the regulation of mRNA cap formation and its impact on mammalian cells. The mRNA cap is a highly methylated modification of the 5’ end of RNA pol II-transcribed RNA. It protects RNA from degradation, recruits complexes involved in RNA processing, export and translation initiation, and marks cellular mRNA as “self” to avoid recognition by the innate immune system. The mRNA cap can be viewed as a unique mark which selects RNA pol II transcripts for specific processing and translation. Over recent years, examples of regulation of mRNA cap formation have emerged, induced by oncogenes, developmental pathways and during the cell cycle. These signalling pathways regulate the rate and extent of mRNA cap formation, resulting in changes in gene expression, cell physiology and cell function.
Original language | English |
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Pages (from-to) | 270-279 |
Number of pages | 10 |
Journal | BBA - Gene Regulatory Mechanisms |
Volume | 1862 |
Issue number | 3 |
Early online date | 9 Oct 2018 |
DOIs | |
Publication status | Published - Mar 2019 |
Keywords
- mRNA
- mRNA cap
- mRNA processing
- transcription
- translation
ASJC Scopus subject areas
- Genetics
- Molecular Biology
- Biophysics
- Structural Biology
- Biochemistry
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Dive into the research topics of 'mRNA cap regulation in mammalian cell function and fate'. Together they form a unique fingerprint.Projects
- 2 Finished
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mRNA Cap Regulation and Function in CD8 T Cells (TCAPS)
Cowling, V. (Investigator)
COMMISSION OF THE EUROPEAN COMMUNITIES
1/05/18 → 30/04/22
Project: Research
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Investigating MRNA Methyl Cap Regulation, Function and Therapeutic Potential (Senior Non-Clinical Fellowship)
Cowling, V. (Investigator)
1/01/14 → 31/12/21
Project: Research