mRNA cap regulation in mammalian cell function and fate

Alison Galloway, Victoria Cowling (Lead / Corresponding author)

Research output: Contribution to journalReview article

4 Citations (Scopus)
28 Downloads (Pure)

Abstract

In this review we explore the regulation of mRNA cap formation and its impact on mammalian cells. The mRNA cap is a highly methylated modification of the 5’ end of RNA pol II-transcribed RNA. It protects RNA from degradation, recruits complexes involved in RNA processing, export and translation initiation, and marks cellular mRNA as “self” to avoid recognition by the innate immune system. The mRNA cap can be viewed as a unique mark which selects RNA pol II transcripts for specific processing and translation. Over recent years, examples of regulation of mRNA cap formation have emerged, induced by oncogenes, developmental pathways and during the cell cycle. These signalling pathways regulate the rate and extent of mRNA cap formation, resulting in changes in gene expression, cell physiology and cell function.
Original languageEnglish
Pages (from-to)270-279
Number of pages10
JournalBiochimica et Biophysica Acta - Gene Regulatory Mechanisms
Volume1862
Issue number3
Early online date9 Oct 2018
DOIs
Publication statusPublished - Mar 2019

Fingerprint

Cells
Messenger RNA
RNA Polymerase II
RNA
Cell Physiological Phenomena
Immune system
RNA Stability
Physiology
Processing
Oncogenes
Gene expression
Immune System
Cell Cycle
Gene Expression
Degradation

Keywords

  • mRNA
  • mRNA cap
  • mRNA processing
  • transcription
  • translation

Cite this

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title = "mRNA cap regulation in mammalian cell function and fate",
abstract = "In this review we explore the regulation of mRNA cap formation and its impact on mammalian cells. The mRNA cap is a highly methylated modification of the 5’ end of RNA pol II-transcribed RNA. It protects RNA from degradation, recruits complexes involved in RNA processing, export and translation initiation, and marks cellular mRNA as “self” to avoid recognition by the innate immune system. The mRNA cap can be viewed as a unique mark which selects RNA pol II transcripts for specific processing and translation. Over recent years, examples of regulation of mRNA cap formation have emerged, induced by oncogenes, developmental pathways and during the cell cycle. These signalling pathways regulate the rate and extent of mRNA cap formation, resulting in changes in gene expression, cell physiology and cell function.",
keywords = "mRNA, mRNA cap, mRNA processing, transcription, translation",
author = "Alison Galloway and Victoria Cowling",
note = "Victoria Cowling and Alison Galloway are funded by a Medical Research Council Senior Fellowship MR/K024213/1, an European Research Council Award 769080 TCAPS and a Royal Society Wolfson Research Merit Award WRM\R1\180008.",
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AU - Cowling, Victoria

N1 - Victoria Cowling and Alison Galloway are funded by a Medical Research Council Senior Fellowship MR/K024213/1, an European Research Council Award 769080 TCAPS and a Royal Society Wolfson Research Merit Award WRM\R1\180008.

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N2 - In this review we explore the regulation of mRNA cap formation and its impact on mammalian cells. The mRNA cap is a highly methylated modification of the 5’ end of RNA pol II-transcribed RNA. It protects RNA from degradation, recruits complexes involved in RNA processing, export and translation initiation, and marks cellular mRNA as “self” to avoid recognition by the innate immune system. The mRNA cap can be viewed as a unique mark which selects RNA pol II transcripts for specific processing and translation. Over recent years, examples of regulation of mRNA cap formation have emerged, induced by oncogenes, developmental pathways and during the cell cycle. These signalling pathways regulate the rate and extent of mRNA cap formation, resulting in changes in gene expression, cell physiology and cell function.

AB - In this review we explore the regulation of mRNA cap formation and its impact on mammalian cells. The mRNA cap is a highly methylated modification of the 5’ end of RNA pol II-transcribed RNA. It protects RNA from degradation, recruits complexes involved in RNA processing, export and translation initiation, and marks cellular mRNA as “self” to avoid recognition by the innate immune system. The mRNA cap can be viewed as a unique mark which selects RNA pol II transcripts for specific processing and translation. Over recent years, examples of regulation of mRNA cap formation have emerged, induced by oncogenes, developmental pathways and during the cell cycle. These signalling pathways regulate the rate and extent of mRNA cap formation, resulting in changes in gene expression, cell physiology and cell function.

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KW - mRNA cap

KW - mRNA processing

KW - transcription

KW - translation

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JO - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

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