mRNA cap regulation in mammalian cell function and fate

Alison Galloway, Victoria Cowling (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

57 Citations (Scopus)
107 Downloads (Pure)

Abstract

In this review we explore the regulation of mRNA cap formation and its impact on mammalian cells. The mRNA cap is a highly methylated modification of the 5’ end of RNA pol II-transcribed RNA. It protects RNA from degradation, recruits complexes involved in RNA processing, export and translation initiation, and marks cellular mRNA as “self” to avoid recognition by the innate immune system. The mRNA cap can be viewed as a unique mark which selects RNA pol II transcripts for specific processing and translation. Over recent years, examples of regulation of mRNA cap formation have emerged, induced by oncogenes, developmental pathways and during the cell cycle. These signalling pathways regulate the rate and extent of mRNA cap formation, resulting in changes in gene expression, cell physiology and cell function.
Original languageEnglish
Pages (from-to)270-279
Number of pages10
JournalBBA - Gene Regulatory Mechanisms
Volume1862
Issue number3
Early online date9 Oct 2018
DOIs
Publication statusPublished - Mar 2019

Keywords

  • mRNA
  • mRNA cap
  • mRNA processing
  • transcription
  • translation

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