MTOR, PIK3C3, and autophagy: Signaling the beginning from the end

Michael J. Munson, Ian G. Ganley (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

121 Citations (Scopus)


A key point in starvation-induced autophagy occurs at the end of the process, where lysosomes are regenerated from autolysosomes through a pathway termed autophagic lysosome reformation (ALR). ALR occurs when autolysosomal MTOR becomes reactivated by amino acids derived from the autophagic delivery of protein cargo. This activation not only turns off autophagosome formation but also leads to reformation of lysosomes, ready for the next round of autophagy, through a series of events involving autolysosomal tubulation. We have now found that MTOR regulates multiple steps of ALR including direct activation of the PIK3C3-UVRAG lipid kinase complex to enable autolysosomal tubules to break away and regenerate lysosomes.

Original languageEnglish
Pages (from-to)2375-2376
Number of pages2
Issue number12
Early online date13 Nov 2015
Publication statusPublished - Dec 2015


  • Autophagic lysosome reformation
  • Lysosome
  • MTOR
  • Phosphatidylinositol 3-phosphate
  • Tubulation
  • VPS34

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology


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