MTOR, PIK3C3, and autophagy: Signaling the beginning from the end

Michael J. Munson, Ian G. Ganley (Lead / Corresponding author)

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

A key point in starvation-induced autophagy occurs at the end of the process, where lysosomes are regenerated from autolysosomes through a pathway termed autophagic lysosome reformation (ALR). ALR occurs when autolysosomal MTOR becomes reactivated by amino acids derived from the autophagic delivery of protein cargo. This activation not only turns off autophagosome formation but also leads to reformation of lysosomes, ready for the next round of autophagy, through a series of events involving autolysosomal tubulation. We have now found that MTOR regulates multiple steps of ALR including direct activation of the PIK3C3-UVRAG lipid kinase complex to enable autolysosomal tubules to break away and regenerate lysosomes.

Original languageEnglish
Pages (from-to)2375-2376
Number of pages2
JournalAutophagy
Volume11
Issue number12
Early online date13 Nov 2015
DOIs
Publication statusPublished - Dec 2015

Keywords

  • Autophagic lysosome reformation
  • Lysosome
  • MTOR
  • Phosphatidylinositol 3-phosphate
  • Tubulation
  • UVRAG
  • VPS34

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