Mucosal immunoglobulins

Jiri Mestecky, Itaru Moro, Michael A. Kerr, Jenny M. Woof

    Research output: Chapter in Book/Report/Conference proceedingChapter

    77 Citations (Scopus)

    Abstract

    The levels of IgA and IgG in human external secretions are well below serum levels and the IgA is dominant in most secretions. Human IgA is heterogenous with respect to its molecular form and subclasses. Plasma or serum IgA is primarily represented by monomeric (m) IgA with two heavy and two light chains. A variable proportion of IgA in human external secretions is present in the form of mIgA and pIgA devoid of secretory component (SC). Most S-IgA in humans is derived from local synthesis and not from the circulation. A relatively high proportion of Ig-producing cells in the mucosal lymphoid tissue is committed to the IgA isotype. This fact-in conjunction with the presence of the specific pIgR expressed on mucosal epithelial cells-accounts for the high relative concentration of IgA in mucosal secretions. In most species, the concentration of IgG in mucosal secretions is approximately the same as or greater than that of IgM. The proportion of IgA to IgG in external secretions not only varies from site to site but also depends on the method and time of collection.
    Original languageEnglish
    Title of host publicationMucosal immunology
    EditorsJiri Mestecky, Michael E. Lamm, Warren Strober, John Bienenstock, Jerry R. McGhee, Lloyd Mayer
    Place of PublicationAmsterdam
    PublisherAcademic Press
    Pages153-181
    Number of pages29
    Volume1
    Edition3rd
    ISBN (Electronic)9780124915435
    ISBN (Print)9780124915442
    DOIs
    Publication statusPublished - 2005

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