Mucosal immunoglobulins

Jenny M. Woof, Jiri Mestecky

Research output: Chapter in Book/Report/Conference proceedingChapter

15 Citations (Scopus)

Abstract

Immunoglobulins (Igs) play key roles in immune protection of mucosal surfaces that form an immense and vulnerable interface with the environment. In humans, the principal Ig in most but not all mucosal secretions is IgA. In some secretions, IgG and IgM contribute toward immune defense. IgA in secretions comprises polymeric (chiefly dimeric) forms of IgA made up of two monomers of IgA, each made up of two heavy or alpha chains and two light chains, linked together via J or joining chain, and covalently associated with secretory component, a polypeptide derived from the receptor responsible for transporting IgA into the sections. The chapter provides an overview of these mucosal Ig components, addressing their evolution, interspecies differences, genes, expression, structural features, and glycosylation.

Original languageEnglish
Title of host publicationMucosal Immunology
Subtitle of host publicationFourth edition
EditorsJiri Mestecky, Warren Strober, Michael W. Russell, Brian L. Kelsall, Hilde Cheroutre, Bart N. Lambrecht
Place of PublicationLondon
PublisherAcademic Press
Pages287-324
Number of pages38
Volume1
Edition4th
ISBN (Print)9780124159754, 9780124158474
DOIs
Publication statusPublished - 15 May 2015

Keywords

  • IgA
  • Immunoglobulin
  • J chain
  • Mucosal immunity
  • PIgR
  • S-IgA
  • Secretory component

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  • Cite this

    Woof, J. M., & Mestecky, J. (2015). Mucosal immunoglobulins. In J. Mestecky, W. Strober, M. W. Russell, B. L. Kelsall, H. Cheroutre, & B. N. Lambrecht (Eds.), Mucosal Immunology: Fourth edition (4th ed., Vol. 1, pp. 287-324). Academic Press. https://doi.org/10.1016/B978-0-12-415847-4.00017-3