Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

Lavinia Paternoster (Lead / Corresponding author), Marie Standl, Johannes Waage, Hansjörg Baurecht, Melanie Hotze, David P. Strachan, John A. Curtin, Klaus Bønnelykke, Chao Tian, Atsushi Takahashi, Jorge Esparza-Gordillo, Alexessander Couto Alves, Jacob P. Thyssen, Herman T. Den Dekker, Manuel A. Ferreira, Elisabeth Altmaier, Patrick M A Sleiman, Feng Li Xiao, Juan R. Gonzalez, Ingo Marenholz & 130 others Birgit Kalb, Maria Pino-Yanes, Cheng Jian Xu, Lisbeth Carstensen, Maria M. Groen-Blokhuis, Cristina Venturini, Craig E. Pennell, Sheila J. Barton, Albert M. Levin, Ivan Curjuric, Mariona Bustamante, Eskil Kreiner-Møller, Gabrielle A. Lockett, Jonas Bacelis, Supinda Bunyavanich, Rachel A. Myers, Anja Matanovic, Ashish Kumar, Joyce Y. Tung, Tomomitsu Hirota, Michiaki Kubo, Wendy L. McArdle, A. John Henderson, John P. Kemp, Jie Zheng, George Davey Smith, Franz Rüschendorf, Anja Bauerfeind, Min Ae Lee-Kirsch, Andreas Arnold, Georg Homuth, Carsten O. Schmidt, Elisabeth Mangold, Sven Cichon, Thomas Keil, Elke Rodríguez, Annette Peters, Andre Franke, Wolfgang Lieb, Natalija Novak, Regina Fölster-Holst, Momoko Horikoshi, Juha Pekkanen, Sylvain Sebert, Lise L. Husemoen, Niels Grarup, Johan C. De Jongste, Fernando Rivadeneira, Albert Hofman, Vincent W V Jaddoe, Suzanne G M A Pasmans, Niels J. Elbert, André G. Uitterlinden, Guy B. Marks, Philip J. Thompson, Melanie C. Matheson, Colin F. Robertson, Janina S. Ried, Jin Li, Xian Bo Zuo, Xiao Dong Zheng, Xian Yong Yin, Liang Dan Sun, Maeve A. McAleer, Grainne M. O'Regan, Caoimhe M R Fahy, Linda E. Campbell, Milan Macek, Michael Kurek, Donglei Hu, Celeste Eng, Dirkje S. Postma, Bjarke Feenstra, Frank Geller, Jouke Jan Hottenga, Christel M. Middeldorp, Pirro Hysi, Veronique Bataille, Tim Spector, Carla M T Tiesler, Elisabeth Thiering, Badri Pahukasahasram, James J. Yang, Medea Imboden, Scott Huntsman, Natàlia Vilor-Tejedor, Caroline L. Relton, Ronny Myhre, Wenche Nystad, Adnan Custovic, Scott T. Weiss, Deborah A. Meyers, Cilla Söderhäll, Erik Melén, Carole Ober, Benjamin A. Raby, Angela Simpson, Bo Jacobsson, John W. Holloway, Hans Bisgaard, Jordi Sunyer, Nicole M. Probst-Hensch, L. Keoki Williams, Keith M. Godfrey, Carol A. Wang, Dorret I. Boomsma, Mads Melbye, Gerard H. Koppelman, Deborah Jarvis, W. H Irwin McLean, Alan D. Irvine, Xue Jun Zhang, Hakon Hakonarson, Christian Gieger, Esteban G. Burchard, Nicholas G. Martin, Liesbeth Duijts, Allan Linneberg, Marjo Riitta Jarvelin, Markus M. Nöthen, Susanne Lau, Norbert Hübner, Young Ae Lee, Mayumi Tamari, David A. Hinds, Daniel Glass, Sara J. Brown, Joachim Heinrich, David M. Evans, Stephan Weidinger

Research output: Contribution to journalLetter

161 Citations (Scopus)

Abstract

Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis.

Original languageEnglish
Pages (from-to)1449-1456
Number of pages8
JournalNature Genetics
Volume47
Issue number12
Early online date19 Oct 2015
DOIs
Publication statusPublished - Dec 2015

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Genome-Wide Association Study
Atopic Dermatitis
Genetic Association Studies
Hispanic Americans
Skin Diseases
Population
Meta-Analysis
T-Lymphocytes
Genes

Cite this

Paternoster, L., Standl, M., Waage, J., Baurecht, H., Hotze, M., Strachan, D. P., ... Weidinger, S. (2015). Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nature Genetics, 47(12), 1449-1456. https://doi.org/10.1038/ng.3424
Paternoster, Lavinia ; Standl, Marie ; Waage, Johannes ; Baurecht, Hansjörg ; Hotze, Melanie ; Strachan, David P. ; Curtin, John A. ; Bønnelykke, Klaus ; Tian, Chao ; Takahashi, Atsushi ; Esparza-Gordillo, Jorge ; Alves, Alexessander Couto ; Thyssen, Jacob P. ; Den Dekker, Herman T. ; Ferreira, Manuel A. ; Altmaier, Elisabeth ; Sleiman, Patrick M A ; Xiao, Feng Li ; Gonzalez, Juan R. ; Marenholz, Ingo ; Kalb, Birgit ; Pino-Yanes, Maria ; Xu, Cheng Jian ; Carstensen, Lisbeth ; Groen-Blokhuis, Maria M. ; Venturini, Cristina ; Pennell, Craig E. ; Barton, Sheila J. ; Levin, Albert M. ; Curjuric, Ivan ; Bustamante, Mariona ; Kreiner-Møller, Eskil ; Lockett, Gabrielle A. ; Bacelis, Jonas ; Bunyavanich, Supinda ; Myers, Rachel A. ; Matanovic, Anja ; Kumar, Ashish ; Tung, Joyce Y. ; Hirota, Tomomitsu ; Kubo, Michiaki ; McArdle, Wendy L. ; Henderson, A. John ; Kemp, John P. ; Zheng, Jie ; Smith, George Davey ; Rüschendorf, Franz ; Bauerfeind, Anja ; Lee-Kirsch, Min Ae ; Arnold, Andreas ; Homuth, Georg ; Schmidt, Carsten O. ; Mangold, Elisabeth ; Cichon, Sven ; Keil, Thomas ; Rodríguez, Elke ; Peters, Annette ; Franke, Andre ; Lieb, Wolfgang ; Novak, Natalija ; Fölster-Holst, Regina ; Horikoshi, Momoko ; Pekkanen, Juha ; Sebert, Sylvain ; Husemoen, Lise L. ; Grarup, Niels ; De Jongste, Johan C. ; Rivadeneira, Fernando ; Hofman, Albert ; Jaddoe, Vincent W V ; Pasmans, Suzanne G M A ; Elbert, Niels J. ; Uitterlinden, André G. ; Marks, Guy B. ; Thompson, Philip J. ; Matheson, Melanie C. ; Robertson, Colin F. ; Ried, Janina S. ; Li, Jin ; Zuo, Xian Bo ; Zheng, Xiao Dong ; Yin, Xian Yong ; Sun, Liang Dan ; McAleer, Maeve A. ; O'Regan, Grainne M. ; Fahy, Caoimhe M R ; Campbell, Linda E. ; Macek, Milan ; Kurek, Michael ; Hu, Donglei ; Eng, Celeste ; Postma, Dirkje S. ; Feenstra, Bjarke ; Geller, Frank ; Hottenga, Jouke Jan ; Middeldorp, Christel M. ; Hysi, Pirro ; Bataille, Veronique ; Spector, Tim ; Tiesler, Carla M T ; Thiering, Elisabeth ; Pahukasahasram, Badri ; Yang, James J. ; Imboden, Medea ; Huntsman, Scott ; Vilor-Tejedor, Natàlia ; Relton, Caroline L. ; Myhre, Ronny ; Nystad, Wenche ; Custovic, Adnan ; Weiss, Scott T. ; Meyers, Deborah A. ; Söderhäll, Cilla ; Melén, Erik ; Ober, Carole ; Raby, Benjamin A. ; Simpson, Angela ; Jacobsson, Bo ; Holloway, John W. ; Bisgaard, Hans ; Sunyer, Jordi ; Probst-Hensch, Nicole M. ; Williams, L. Keoki ; Godfrey, Keith M. ; Wang, Carol A. ; Boomsma, Dorret I. ; Melbye, Mads ; Koppelman, Gerard H. ; Jarvis, Deborah ; McLean, W. H Irwin ; Irvine, Alan D. ; Zhang, Xue Jun ; Hakonarson, Hakon ; Gieger, Christian ; Burchard, Esteban G. ; Martin, Nicholas G. ; Duijts, Liesbeth ; Linneberg, Allan ; Jarvelin, Marjo Riitta ; Nöthen, Markus M. ; Lau, Susanne ; Hübner, Norbert ; Lee, Young Ae ; Tamari, Mayumi ; Hinds, David A. ; Glass, Daniel ; Brown, Sara J. ; Heinrich, Joachim ; Evans, David M. ; Weidinger, Stephan. / Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. In: Nature Genetics. 2015 ; Vol. 47, No. 12. pp. 1449-1456.
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title = "Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis",
abstract = "Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis.",
author = "Lavinia Paternoster and Marie Standl and Johannes Waage and Hansj{\"o}rg Baurecht and Melanie Hotze and Strachan, {David P.} and Curtin, {John A.} and Klaus B{\o}nnelykke and Chao Tian and Atsushi Takahashi and Jorge Esparza-Gordillo and Alves, {Alexessander Couto} and Thyssen, {Jacob P.} and {Den Dekker}, {Herman T.} and Ferreira, {Manuel A.} and Elisabeth Altmaier and Sleiman, {Patrick M A} and Xiao, {Feng Li} and Gonzalez, {Juan R.} and Ingo Marenholz and Birgit Kalb and Maria Pino-Yanes and Xu, {Cheng Jian} and Lisbeth Carstensen and Groen-Blokhuis, {Maria M.} and Cristina Venturini and Pennell, {Craig E.} and Barton, {Sheila J.} and Levin, {Albert M.} and Ivan Curjuric and Mariona Bustamante and Eskil Kreiner-M{\o}ller and Lockett, {Gabrielle A.} and Jonas Bacelis and Supinda Bunyavanich and Myers, {Rachel A.} and Anja Matanovic and Ashish Kumar and Tung, {Joyce Y.} and Tomomitsu Hirota and Michiaki Kubo and McArdle, {Wendy L.} and Henderson, {A. John} and Kemp, {John P.} and Jie Zheng and Smith, {George Davey} and Franz R{\"u}schendorf and Anja Bauerfeind and Lee-Kirsch, {Min Ae} and Andreas Arnold and Georg Homuth and Schmidt, {Carsten O.} and Elisabeth Mangold and Sven Cichon and Thomas Keil and Elke Rodr{\'i}guez and Annette Peters and Andre Franke and Wolfgang Lieb and Natalija Novak and Regina F{\"o}lster-Holst and Momoko Horikoshi and Juha Pekkanen and Sylvain Sebert and Husemoen, {Lise L.} and Niels Grarup and {De Jongste}, {Johan C.} and Fernando Rivadeneira and Albert Hofman and Jaddoe, {Vincent W V} and Pasmans, {Suzanne G M A} and Elbert, {Niels J.} and Uitterlinden, {Andr{\'e} G.} and Marks, {Guy B.} and Thompson, {Philip J.} and Matheson, {Melanie C.} and Robertson, {Colin F.} and Ried, {Janina S.} and Jin Li and Zuo, {Xian Bo} and Zheng, {Xiao Dong} and Yin, {Xian Yong} and Sun, {Liang Dan} and McAleer, {Maeve A.} and O'Regan, {Grainne M.} and Fahy, {Caoimhe M R} and Campbell, {Linda E.} and Milan Macek and Michael Kurek and Donglei Hu and Celeste Eng and Postma, {Dirkje S.} and Bjarke Feenstra and Frank Geller and Hottenga, {Jouke Jan} and Middeldorp, {Christel M.} and Pirro Hysi and Veronique Bataille and Tim Spector and Tiesler, {Carla M T} and Elisabeth Thiering and Badri Pahukasahasram and Yang, {James J.} and Medea Imboden and Scott Huntsman and Nat{\`a}lia Vilor-Tejedor and Relton, {Caroline L.} and Ronny Myhre and Wenche Nystad and Adnan Custovic and Weiss, {Scott T.} and Meyers, {Deborah A.} and Cilla S{\"o}derh{\"a}ll and Erik Mel{\'e}n and Carole Ober and Raby, {Benjamin A.} and Angela Simpson and Bo Jacobsson and Holloway, {John W.} and Hans Bisgaard and Jordi Sunyer and Probst-Hensch, {Nicole M.} and Williams, {L. Keoki} and Godfrey, {Keith M.} and Wang, {Carol A.} and Boomsma, {Dorret I.} and Mads Melbye and Koppelman, {Gerard H.} and Deborah Jarvis and McLean, {W. H Irwin} and Irvine, {Alan D.} and Zhang, {Xue Jun} and Hakon Hakonarson and Christian Gieger and Burchard, {Esteban G.} and Martin, {Nicholas G.} and Liesbeth Duijts and Allan Linneberg and Jarvelin, {Marjo Riitta} and N{\"o}then, {Markus M.} and Susanne Lau and Norbert H{\"u}bner and Lee, {Young Ae} and Mayumi Tamari and Hinds, {David A.} and Daniel Glass and Brown, {Sara J.} and Joachim Heinrich and Evans, {David M.} and Stephan Weidinger",
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Paternoster, L, Standl, M, Waage, J, Baurecht, H, Hotze, M, Strachan, DP, Curtin, JA, Bønnelykke, K, Tian, C, Takahashi, A, Esparza-Gordillo, J, Alves, AC, Thyssen, JP, Den Dekker, HT, Ferreira, MA, Altmaier, E, Sleiman, PMA, Xiao, FL, Gonzalez, JR, Marenholz, I, Kalb, B, Pino-Yanes, M, Xu, CJ, Carstensen, L, Groen-Blokhuis, MM, Venturini, C, Pennell, CE, Barton, SJ, Levin, AM, Curjuric, I, Bustamante, M, Kreiner-Møller, E, Lockett, GA, Bacelis, J, Bunyavanich, S, Myers, RA, Matanovic, A, Kumar, A, Tung, JY, Hirota, T, Kubo, M, McArdle, WL, Henderson, AJ, Kemp, JP, Zheng, J, Smith, GD, Rüschendorf, F, Bauerfeind, A, Lee-Kirsch, MA, Arnold, A, Homuth, G, Schmidt, CO, Mangold, E, Cichon, S, Keil, T, Rodríguez, E, Peters, A, Franke, A, Lieb, W, Novak, N, Fölster-Holst, R, Horikoshi, M, Pekkanen, J, Sebert, S, Husemoen, LL, Grarup, N, De Jongste, JC, Rivadeneira, F, Hofman, A, Jaddoe, VWV, Pasmans, SGMA, Elbert, NJ, Uitterlinden, AG, Marks, GB, Thompson, PJ, Matheson, MC, Robertson, CF, Ried, JS, Li, J, Zuo, XB, Zheng, XD, Yin, XY, Sun, LD, McAleer, MA, O'Regan, GM, Fahy, CMR, Campbell, LE, Macek, M, Kurek, M, Hu, D, Eng, C, Postma, DS, Feenstra, B, Geller, F, Hottenga, JJ, Middeldorp, CM, Hysi, P, Bataille, V, Spector, T, Tiesler, CMT, Thiering, E, Pahukasahasram, B, Yang, JJ, Imboden, M, Huntsman, S, Vilor-Tejedor, N, Relton, CL, Myhre, R, Nystad, W, Custovic, A, Weiss, ST, Meyers, DA, Söderhäll, C, Melén, E, Ober, C, Raby, BA, Simpson, A, Jacobsson, B, Holloway, JW, Bisgaard, H, Sunyer, J, Probst-Hensch, NM, Williams, LK, Godfrey, KM, Wang, CA, Boomsma, DI, Melbye, M, Koppelman, GH, Jarvis, D, McLean, WHI, Irvine, AD, Zhang, XJ, Hakonarson, H, Gieger, C, Burchard, EG, Martin, NG, Duijts, L, Linneberg, A, Jarvelin, MR, Nöthen, MM, Lau, S, Hübner, N, Lee, YA, Tamari, M, Hinds, DA, Glass, D, Brown, SJ, Heinrich, J, Evans, DM & Weidinger, S 2015, 'Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis', Nature Genetics, vol. 47, no. 12, pp. 1449-1456. https://doi.org/10.1038/ng.3424

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. / Paternoster, Lavinia (Lead / Corresponding author); Standl, Marie; Waage, Johannes; Baurecht, Hansjörg; Hotze, Melanie; Strachan, David P.; Curtin, John A.; Bønnelykke, Klaus; Tian, Chao; Takahashi, Atsushi; Esparza-Gordillo, Jorge; Alves, Alexessander Couto; Thyssen, Jacob P.; Den Dekker, Herman T.; Ferreira, Manuel A.; Altmaier, Elisabeth; Sleiman, Patrick M A; Xiao, Feng Li; Gonzalez, Juan R.; Marenholz, Ingo; Kalb, Birgit; Pino-Yanes, Maria; Xu, Cheng Jian; Carstensen, Lisbeth; Groen-Blokhuis, Maria M.; Venturini, Cristina; Pennell, Craig E.; Barton, Sheila J.; Levin, Albert M.; Curjuric, Ivan; Bustamante, Mariona; Kreiner-Møller, Eskil; Lockett, Gabrielle A.; Bacelis, Jonas; Bunyavanich, Supinda; Myers, Rachel A.; Matanovic, Anja; Kumar, Ashish; Tung, Joyce Y.; Hirota, Tomomitsu; Kubo, Michiaki; McArdle, Wendy L.; Henderson, A. John; Kemp, John P.; Zheng, Jie; Smith, George Davey; Rüschendorf, Franz; Bauerfeind, Anja; Lee-Kirsch, Min Ae; Arnold, Andreas; Homuth, Georg; Schmidt, Carsten O.; Mangold, Elisabeth; Cichon, Sven; Keil, Thomas; Rodríguez, Elke; Peters, Annette; Franke, Andre; Lieb, Wolfgang; Novak, Natalija; Fölster-Holst, Regina; Horikoshi, Momoko; Pekkanen, Juha; Sebert, Sylvain; Husemoen, Lise L.; Grarup, Niels; De Jongste, Johan C.; Rivadeneira, Fernando; Hofman, Albert; Jaddoe, Vincent W V; Pasmans, Suzanne G M A; Elbert, Niels J.; Uitterlinden, André G.; Marks, Guy B.; Thompson, Philip J.; Matheson, Melanie C.; Robertson, Colin F.; Ried, Janina S.; Li, Jin; Zuo, Xian Bo; Zheng, Xiao Dong; Yin, Xian Yong; Sun, Liang Dan; McAleer, Maeve A.; O'Regan, Grainne M.; Fahy, Caoimhe M R; Campbell, Linda E.; Macek, Milan; Kurek, Michael; Hu, Donglei; Eng, Celeste; Postma, Dirkje S.; Feenstra, Bjarke; Geller, Frank; Hottenga, Jouke Jan; Middeldorp, Christel M.; Hysi, Pirro; Bataille, Veronique; Spector, Tim; Tiesler, Carla M T; Thiering, Elisabeth; Pahukasahasram, Badri; Yang, James J.; Imboden, Medea; Huntsman, Scott; Vilor-Tejedor, Natàlia; Relton, Caroline L.; Myhre, Ronny; Nystad, Wenche; Custovic, Adnan; Weiss, Scott T.; Meyers, Deborah A.; Söderhäll, Cilla; Melén, Erik; Ober, Carole; Raby, Benjamin A.; Simpson, Angela; Jacobsson, Bo; Holloway, John W.; Bisgaard, Hans; Sunyer, Jordi; Probst-Hensch, Nicole M.; Williams, L. Keoki; Godfrey, Keith M.; Wang, Carol A.; Boomsma, Dorret I.; Melbye, Mads; Koppelman, Gerard H.; Jarvis, Deborah; McLean, W. H Irwin; Irvine, Alan D.; Zhang, Xue Jun; Hakonarson, Hakon; Gieger, Christian; Burchard, Esteban G.; Martin, Nicholas G.; Duijts, Liesbeth; Linneberg, Allan; Jarvelin, Marjo Riitta; Nöthen, Markus M.; Lau, Susanne; Hübner, Norbert; Lee, Young Ae; Tamari, Mayumi; Hinds, David A.; Glass, Daniel; Brown, Sara J.; Heinrich, Joachim; Evans, David M.; Weidinger, Stephan.

In: Nature Genetics, Vol. 47, No. 12, 12.2015, p. 1449-1456.

Research output: Contribution to journalLetter

TY - JOUR

T1 - Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

AU - Paternoster, Lavinia

AU - Standl, Marie

AU - Waage, Johannes

AU - Baurecht, Hansjörg

AU - Hotze, Melanie

AU - Strachan, David P.

AU - Curtin, John A.

AU - Bønnelykke, Klaus

AU - Tian, Chao

AU - Takahashi, Atsushi

AU - Esparza-Gordillo, Jorge

AU - Alves, Alexessander Couto

AU - Thyssen, Jacob P.

AU - Den Dekker, Herman T.

AU - Ferreira, Manuel A.

AU - Altmaier, Elisabeth

AU - Sleiman, Patrick M A

AU - Xiao, Feng Li

AU - Gonzalez, Juan R.

AU - Marenholz, Ingo

AU - Kalb, Birgit

AU - Pino-Yanes, Maria

AU - Xu, Cheng Jian

AU - Carstensen, Lisbeth

AU - Groen-Blokhuis, Maria M.

AU - Venturini, Cristina

AU - Pennell, Craig E.

AU - Barton, Sheila J.

AU - Levin, Albert M.

AU - Curjuric, Ivan

AU - Bustamante, Mariona

AU - Kreiner-Møller, Eskil

AU - Lockett, Gabrielle A.

AU - Bacelis, Jonas

AU - Bunyavanich, Supinda

AU - Myers, Rachel A.

AU - Matanovic, Anja

AU - Kumar, Ashish

AU - Tung, Joyce Y.

AU - Hirota, Tomomitsu

AU - Kubo, Michiaki

AU - McArdle, Wendy L.

AU - Henderson, A. John

AU - Kemp, John P.

AU - Zheng, Jie

AU - Smith, George Davey

AU - Rüschendorf, Franz

AU - Bauerfeind, Anja

AU - Lee-Kirsch, Min Ae

AU - Arnold, Andreas

AU - Homuth, Georg

AU - Schmidt, Carsten O.

AU - Mangold, Elisabeth

AU - Cichon, Sven

AU - Keil, Thomas

AU - Rodríguez, Elke

AU - Peters, Annette

AU - Franke, Andre

AU - Lieb, Wolfgang

AU - Novak, Natalija

AU - Fölster-Holst, Regina

AU - Horikoshi, Momoko

AU - Pekkanen, Juha

AU - Sebert, Sylvain

AU - Husemoen, Lise L.

AU - Grarup, Niels

AU - De Jongste, Johan C.

AU - Rivadeneira, Fernando

AU - Hofman, Albert

AU - Jaddoe, Vincent W V

AU - Pasmans, Suzanne G M A

AU - Elbert, Niels J.

AU - Uitterlinden, André G.

AU - Marks, Guy B.

AU - Thompson, Philip J.

AU - Matheson, Melanie C.

AU - Robertson, Colin F.

AU - Ried, Janina S.

AU - Li, Jin

AU - Zuo, Xian Bo

AU - Zheng, Xiao Dong

AU - Yin, Xian Yong

AU - Sun, Liang Dan

AU - McAleer, Maeve A.

AU - O'Regan, Grainne M.

AU - Fahy, Caoimhe M R

AU - Campbell, Linda E.

AU - Macek, Milan

AU - Kurek, Michael

AU - Hu, Donglei

AU - Eng, Celeste

AU - Postma, Dirkje S.

AU - Feenstra, Bjarke

AU - Geller, Frank

AU - Hottenga, Jouke Jan

AU - Middeldorp, Christel M.

AU - Hysi, Pirro

AU - Bataille, Veronique

AU - Spector, Tim

AU - Tiesler, Carla M T

AU - Thiering, Elisabeth

AU - Pahukasahasram, Badri

AU - Yang, James J.

AU - Imboden, Medea

AU - Huntsman, Scott

AU - Vilor-Tejedor, Natàlia

AU - Relton, Caroline L.

AU - Myhre, Ronny

AU - Nystad, Wenche

AU - Custovic, Adnan

AU - Weiss, Scott T.

AU - Meyers, Deborah A.

AU - Söderhäll, Cilla

AU - Melén, Erik

AU - Ober, Carole

AU - Raby, Benjamin A.

AU - Simpson, Angela

AU - Jacobsson, Bo

AU - Holloway, John W.

AU - Bisgaard, Hans

AU - Sunyer, Jordi

AU - Probst-Hensch, Nicole M.

AU - Williams, L. Keoki

AU - Godfrey, Keith M.

AU - Wang, Carol A.

AU - Boomsma, Dorret I.

AU - Melbye, Mads

AU - Koppelman, Gerard H.

AU - Jarvis, Deborah

AU - McLean, W. H Irwin

AU - Irvine, Alan D.

AU - Zhang, Xue Jun

AU - Hakonarson, Hakon

AU - Gieger, Christian

AU - Burchard, Esteban G.

AU - Martin, Nicholas G.

AU - Duijts, Liesbeth

AU - Linneberg, Allan

AU - Jarvelin, Marjo Riitta

AU - Nöthen, Markus M.

AU - Lau, Susanne

AU - Hübner, Norbert

AU - Lee, Young Ae

AU - Tamari, Mayumi

AU - Hinds, David A.

AU - Glass, Daniel

AU - Brown, Sara J.

AU - Heinrich, Joachim

AU - Evans, David M.

AU - Weidinger, Stephan

PY - 2015/12

Y1 - 2015/12

N2 - Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis.

AB - Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis.

UR - http://www.scopus.com/inward/record.url?scp=84949087646&partnerID=8YFLogxK

U2 - 10.1038/ng.3424

DO - 10.1038/ng.3424

M3 - Letter

VL - 47

SP - 1449

EP - 1456

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 12

ER -