Multi-Scale Mathematical Modelling and Simulations of Chemo-Viro-Therapies for Cancer

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

Abstract

Oncolytic viruses (OVs) have gained increasing attention in cancer research due to their immunotherapeutic potential and low side effect profile. However, OVs have been typically used so far as monotherapy and that resulted in limited efficacy. To address this issue, OVs are increasingly being combined with chemotherapies. In this chapter, we develop a multi-scale mathematical model to study the interactions between tumour cells, chemovirotherapy, and the extracellular matrix (ECM). Our model shows that either monotherapy is less effective than the combination therapy, which is consistent with experimental results.
Original languageEnglish
Title of host publicationModelling and Computational Approaches for Multi-Scale Phenomena in Cancer Research
Subtitle of host publicationFrom Cancer Evolution to Cancer Treatment
EditorsRaluca Eftimie, Dumitru Trucu
Place of PublicationSingapore
PublisherWorld Scientific
Chapter6
Pages149-180
ISBN (Electronic)9781800614383, 9781800614390
ISBN (Print)9781800614376
DOIs
Publication statusPublished - Dec 2024

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