Multiagonist Unimolecular Peptides for Obesity and Type 2 Diabetes: Current Advances and Future Directions

Annie Hasib (Lead / Corresponding author)

Research output: Contribution to journalReview article

1 Citation (Scopus)
42 Downloads (Pure)

Abstract

The ever-increasing prevalence of obesity and Type 2 diabetes has necessitated the development of newer and more effective approaches for achieving efficient glycemic control and weight loss. Conventional treatment methods often result in weight gain, further deteriorating the already impaired metabolic control in people with obesity/Type 2 diabetes. Alleviation of obesity and diabetes achieved after bariatric surgeries highlight the therapeutic importance of gut-brain axis and entails development of more patient-friendly approaches replicating the positive metabolic effects of bariatric surgery. Given the potential involvement of several gut hormones in the success of bariatric surgery, the therapeutic importance of synergistic interaction between these hormones for improved metabolism cannot be ignored. Many unimolecular multiagonist peptides are in preclinical and clinical trials as they maximize the combinatorial metabolic efficacy by concurrent activation of multiple gut hormone receptors. This review summarizes the ongoing developments of multiagonist peptides as novel therapeutic approaches against obesity-diabetes.

Original languageEnglish
Number of pages8
JournalClinical Medicine Insights: Endocrinology and Diabetes
Volume13
Early online date14 Feb 2020
DOIs
Publication statusE-pub ahead of print - 14 Feb 2020

Keywords

  • agonist
  • diabetes
  • Glucagon-like-peptide-1 (GLP-1)
  • glucose-dependent insulinotropic polypeptide (GIP)
  • hybrid
  • obesity
  • unimolecular

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