Multicenter Study of the Association between Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma

Jan Nico Bouwes Bavinck; Rachel E. Neale; Damiano Abeni; Sylvie Euvrard; Adele C. Green; Catherine A. Harwood; Maurits N. C. de Koning; Luigi Naldi; Ingo Nindl; Michael Pawlita; Herbert Pfister; Charlotte M. Proby; Wim G. V. Quint; Jan ter Schegget; Tim Waterboer; Soenke Weissenborn; Mariet C. W. Feltkamp; EPI-HPV-UV-CA Grp

doi:10.1158/0008-5472.CAN-10-0352

Multicenter Study of the Association between Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma

Jan Nico Bouwes Bavinck
, Rachel E. Neale
, Damiano Abeni
, Sylvie Euvrard
, Adele C. Green
, Catherine A. Harwood
, Maurits N. C. de Koning
, Luigi Naldi
, Ingo Nindl
, Michael Pawlita
, Herbert Pfister
, Charlotte M. Proby
, Wim G. V. Quint
, Jan ter Schegget
, Tim Waterboer
, Soenke Weissenborn
, Mariet C. W. Feltkamp
, EPI-HPV-UV-CA Grp

Research output: Contribution to journal › Article › peer-review

126 Citations (Scopus)

Abstract

Human papillomaviruses (betaPV) from the beta genus cannot be classified according to their oncogenicity due to a paucity of information. This study evaluates the association between betaPV infection and cutaneous squamous cell carcinoma in conjunction with measures of UV exposure and susceptibility. We performed case-control studies in the Netherlands, Italy, and Australia, countries with profoundly different UV exposures. The presence of 25 betaPV types in eyebrow hair follicles was determined using a highly sensitive HPV DNA genotyping assay, and antibodies for the 15 most prevalent betaPV types in a total of 689 squamous cell carcinoma cases and 845 controls were detected using multiplex serology. Multivariate logistic regression models were used for case-control comparisons and interaction analyses. BetaPV DNA was detected in eyebrow hairs of more than 90% of all participants. The presence of betaPV DNA was associated with an increased risk of squamous cell carcinoma in the Netherlands (OR 2.8; 95% CI 1.3-5.8) and Italy (OR 1.7; 95% CI 0.79-3.6), but not in Australia (OR 0.91; 95% CI 0.53-1.6). Seropositivity for betaPV in controls ranged between 52% and 67%. A positive antibody response against 4 or more betaPV types was associated with squamous cell carcinoma in Australia (OR 2.2; 95% CI 1.4-3.3), the Netherlands (OR 2.0; 95% CI 1.2-3.4) and fair-skinned Italians (OR 1.6, 95% CI 0.94-2.7). The association between UV susceptibility and squamous cell carcinoma was stronger in betaPV-seropositive people. These combined data support the hypothesis that betaPV may play a role in the development of cutaneous squamous cell carcinoma. Cancer Res; 70(23); 9777-86. (C)2010 AACR.

Original language	English
Pages (from-to)	9777-9786
Number of pages	10
Journal	Cancer Research
Volume	70
Issue number	23
DOIs	https://doi.org/10.1158/0008-5472.CAN-10-0352
Publication status	Published - 1 Dec 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

HUMAN-PAPILLOMAVIRUS-DNA
RENAL-TRANSPLANT RECIPIENTS
KERATOTIC SKIN-LESIONS
EPIDERMODYSPLASIA-VERRUCIFORMIS
ACTINIC KERATOSES
E6 PROTEINS
INDUCED APOPTOSIS
RISK-FACTORS
CANCER
BETA

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10.1158/0008-5472.CAN-10-0352

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Bavinck, J. N. B., Neale, R. E., Abeni, D., Euvrard, S., Green, A. C., Harwood, C. A., de Koning, M. N. C., Naldi, L., Nindl, I., Pawlita, M., Pfister, H., Proby, C. M., Quint, W. G. V., ter Schegget, J., Waterboer, T., Weissenborn, S., Feltkamp, M. C. W., & EPI-HPV-UV-CA Grp (2010). Multicenter Study of the Association between Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma. Cancer Research, 70(23), 9777-9786. https://doi.org/10.1158/0008-5472.CAN-10-0352

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title = "Multicenter Study of the Association between Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma",

abstract = "Human papillomaviruses (betaPV) from the beta genus cannot be classified according to their oncogenicity due to a paucity of information. This study evaluates the association between betaPV infection and cutaneous squamous cell carcinoma in conjunction with measures of UV exposure and susceptibility. We performed case-control studies in the Netherlands, Italy, and Australia, countries with profoundly different UV exposures. The presence of 25 betaPV types in eyebrow hair follicles was determined using a highly sensitive HPV DNA genotyping assay, and antibodies for the 15 most prevalent betaPV types in a total of 689 squamous cell carcinoma cases and 845 controls were detected using multiplex serology. Multivariate logistic regression models were used for case-control comparisons and interaction analyses. BetaPV DNA was detected in eyebrow hairs of more than 90\% of all participants. The presence of betaPV DNA was associated with an increased risk of squamous cell carcinoma in the Netherlands (OR 2.8; 95\% CI 1.3-5.8) and Italy (OR 1.7; 95\% CI 0.79-3.6), but not in Australia (OR 0.91; 95\% CI 0.53-1.6). Seropositivity for betaPV in controls ranged between 52\% and 67\%. A positive antibody response against 4 or more betaPV types was associated with squamous cell carcinoma in Australia (OR 2.2; 95\% CI 1.4-3.3), the Netherlands (OR 2.0; 95\% CI 1.2-3.4) and fair-skinned Italians (OR 1.6, 95\% CI 0.94-2.7). The association between UV susceptibility and squamous cell carcinoma was stronger in betaPV-seropositive people. These combined data support the hypothesis that betaPV may play a role in the development of cutaneous squamous cell carcinoma. Cancer Res; 70(23); 9777-86. (C)2010 AACR.",

keywords = "HUMAN-PAPILLOMAVIRUS-DNA, RENAL-TRANSPLANT RECIPIENTS, KERATOTIC SKIN-LESIONS, EPIDERMODYSPLASIA-VERRUCIFORMIS, ACTINIC KERATOSES, E6 PROTEINS, INDUCED APOPTOSIS, RISK-FACTORS, CANCER, BETA",

author = "Bavinck, \{Jan Nico Bouwes\} and Neale, \{Rachel E.\} and Damiano Abeni and Sylvie Euvrard and Green, \{Adele C.\} and Harwood, \{Catherine A.\} and \{de Koning\}, \{Maurits N. C.\} and Luigi Naldi and Ingo Nindl and Michael Pawlita and Herbert Pfister and Proby, \{Charlotte M.\} and Quint, \{Wim G. V.\} and \{ter Schegget\}, Jan and Tim Waterboer and Soenke Weissenborn and Feltkamp, \{Mariet C. W.\} and \{EPI-HPV-UV-CA Grp\}",

year = "2010",

month = dec,

day = "1",

doi = "10.1158/0008-5472.CAN-10-0352",

language = "English",

volume = "70",

pages = "9777--9786",

journal = "Cancer Research",

issn = "0008-5472",

publisher = "American Association for Cancer Research Inc.",

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Bavinck, JNB, Neale, RE, Abeni, D, Euvrard, S, Green, AC, Harwood, CA, de Koning, MNC, Naldi, L, Nindl, I, Pawlita, M, Pfister, H, Proby, CM, Quint, WGV, ter Schegget, J, Waterboer, T, Weissenborn, S, Feltkamp, MCW & EPI-HPV-UV-CA Grp 2010, 'Multicenter Study of the Association between Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma', Cancer Research, vol. 70, no. 23, pp. 9777-9786. https://doi.org/10.1158/0008-5472.CAN-10-0352

TY - JOUR

T1 - Multicenter Study of the Association between Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma

AU - Bavinck, Jan Nico Bouwes

AU - Neale, Rachel E.

AU - Abeni, Damiano

AU - Euvrard, Sylvie

AU - Green, Adele C.

AU - Harwood, Catherine A.

AU - de Koning, Maurits N. C.

AU - Naldi, Luigi

AU - Nindl, Ingo

AU - Pawlita, Michael

AU - Pfister, Herbert

AU - Proby, Charlotte M.

AU - Quint, Wim G. V.

AU - ter Schegget, Jan

AU - Waterboer, Tim

AU - Weissenborn, Soenke

AU - Feltkamp, Mariet C. W.

AU - EPI-HPV-UV-CA Grp

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Human papillomaviruses (betaPV) from the beta genus cannot be classified according to their oncogenicity due to a paucity of information. This study evaluates the association between betaPV infection and cutaneous squamous cell carcinoma in conjunction with measures of UV exposure and susceptibility. We performed case-control studies in the Netherlands, Italy, and Australia, countries with profoundly different UV exposures. The presence of 25 betaPV types in eyebrow hair follicles was determined using a highly sensitive HPV DNA genotyping assay, and antibodies for the 15 most prevalent betaPV types in a total of 689 squamous cell carcinoma cases and 845 controls were detected using multiplex serology. Multivariate logistic regression models were used for case-control comparisons and interaction analyses. BetaPV DNA was detected in eyebrow hairs of more than 90% of all participants. The presence of betaPV DNA was associated with an increased risk of squamous cell carcinoma in the Netherlands (OR 2.8; 95% CI 1.3-5.8) and Italy (OR 1.7; 95% CI 0.79-3.6), but not in Australia (OR 0.91; 95% CI 0.53-1.6). Seropositivity for betaPV in controls ranged between 52% and 67%. A positive antibody response against 4 or more betaPV types was associated with squamous cell carcinoma in Australia (OR 2.2; 95% CI 1.4-3.3), the Netherlands (OR 2.0; 95% CI 1.2-3.4) and fair-skinned Italians (OR 1.6, 95% CI 0.94-2.7). The association between UV susceptibility and squamous cell carcinoma was stronger in betaPV-seropositive people. These combined data support the hypothesis that betaPV may play a role in the development of cutaneous squamous cell carcinoma. Cancer Res; 70(23); 9777-86. (C)2010 AACR.

AB - Human papillomaviruses (betaPV) from the beta genus cannot be classified according to their oncogenicity due to a paucity of information. This study evaluates the association between betaPV infection and cutaneous squamous cell carcinoma in conjunction with measures of UV exposure and susceptibility. We performed case-control studies in the Netherlands, Italy, and Australia, countries with profoundly different UV exposures. The presence of 25 betaPV types in eyebrow hair follicles was determined using a highly sensitive HPV DNA genotyping assay, and antibodies for the 15 most prevalent betaPV types in a total of 689 squamous cell carcinoma cases and 845 controls were detected using multiplex serology. Multivariate logistic regression models were used for case-control comparisons and interaction analyses. BetaPV DNA was detected in eyebrow hairs of more than 90% of all participants. The presence of betaPV DNA was associated with an increased risk of squamous cell carcinoma in the Netherlands (OR 2.8; 95% CI 1.3-5.8) and Italy (OR 1.7; 95% CI 0.79-3.6), but not in Australia (OR 0.91; 95% CI 0.53-1.6). Seropositivity for betaPV in controls ranged between 52% and 67%. A positive antibody response against 4 or more betaPV types was associated with squamous cell carcinoma in Australia (OR 2.2; 95% CI 1.4-3.3), the Netherlands (OR 2.0; 95% CI 1.2-3.4) and fair-skinned Italians (OR 1.6, 95% CI 0.94-2.7). The association between UV susceptibility and squamous cell carcinoma was stronger in betaPV-seropositive people. These combined data support the hypothesis that betaPV may play a role in the development of cutaneous squamous cell carcinoma. Cancer Res; 70(23); 9777-86. (C)2010 AACR.

KW - HUMAN-PAPILLOMAVIRUS-DNA

KW - RENAL-TRANSPLANT RECIPIENTS

KW - KERATOTIC SKIN-LESIONS

KW - EPIDERMODYSPLASIA-VERRUCIFORMIS

KW - ACTINIC KERATOSES

KW - E6 PROTEINS

KW - INDUCED APOPTOSIS

KW - RISK-FACTORS

KW - CANCER

KW - BETA

U2 - 10.1158/0008-5472.CAN-10-0352

DO - 10.1158/0008-5472.CAN-10-0352

M3 - Article

C2 - 21098702

SN - 0008-5472

VL - 70

SP - 9777

EP - 9786

JO - Cancer Research

JF - Cancer Research

IS - 23

ER -

Multicenter Study of the Association between Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma

Abstract

UN SDGs

Keywords

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