TY - JOUR
T1 - Multidetector Computed Tomography Imaging
T2 - Effect of Sparse Sampling and Iterative Reconstruction on Trabecular Bone Microstructure
AU - Mookiah, Muthu Rama Krishnan
AU - Subburaj, Karupppasamy
AU - Mei, Kai
AU - Kopp, Felix K.
AU - Kaesmacher, J.
AU - Jungmann, P.M.
AU - Foehr, Peter
AU - Noel, Peter B.
AU - Kirschke, J.S.
AU - Baum, Thomas J.
PY - 2018/5
Y1 - 2018/5
N2 - Multidetector computed tomography–based trabecular bone microstructure analysis ensures promising results in fracture risk prediction caused by osteoporosis. Because multidetector computed tomography is associated with high radiation exposure, its clinical routine use is limited. Hence, in this study, we investigated in 11 thoracic midvertebral specimens whether trabecular texture parameters are comparable derived from (1) images reconstructed using statistical iterative reconstruction (SIR) and filtered back projection as criterion standard at different exposures (80, 150, 220, and 500 mAs) and (2) from SIR-based sparse sampling projections (12.5%, 25%, 50%, and 100%) and equivalent exposures as criterion standard. Twenty-four texture features were computed, and those that showed similar values between (1) filtered back projection and SIR at the different exposure levels and (2) sparse sampling and equivalent exposures and reconstructed with SIR were identified. These parameters can be of equal value in determining trabecular bone microstructure with lower radiation exposure using sparse sampling and SIR.
AB - Multidetector computed tomography–based trabecular bone microstructure analysis ensures promising results in fracture risk prediction caused by osteoporosis. Because multidetector computed tomography is associated with high radiation exposure, its clinical routine use is limited. Hence, in this study, we investigated in 11 thoracic midvertebral specimens whether trabecular texture parameters are comparable derived from (1) images reconstructed using statistical iterative reconstruction (SIR) and filtered back projection as criterion standard at different exposures (80, 150, 220, and 500 mAs) and (2) from SIR-based sparse sampling projections (12.5%, 25%, 50%, and 100%) and equivalent exposures as criterion standard. Twenty-four texture features were computed, and those that showed similar values between (1) filtered back projection and SIR at the different exposure levels and (2) sparse sampling and equivalent exposures and reconstructed with SIR were identified. These parameters can be of equal value in determining trabecular bone microstructure with lower radiation exposure using sparse sampling and SIR.
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-85047393500&partnerID=MN8TOARS
U2 - 10.1097/RCT.0000000000000710
DO - 10.1097/RCT.0000000000000710
M3 - Article
SN - 1532-3145
VL - 42
SP - 441
EP - 447
JO - Journal of Computer Assisted Tomography
JF - Journal of Computer Assisted Tomography
IS - 3
ER -