Multidimentional proteomics for cell biology

Mark Larance (Lead / Corresponding author), Angus I. Lamond (Lead / Corresponding author)

    Research output: Contribution to journalArticlepeer-review

    324 Citations (Scopus)
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    The proteome is a dynamic system in which each protein has interconnected properties — dimensions — that together contribute to the phenotype of a cell. Measuring these properties has proved challenging owing to their diversity and dynamic nature. Advances in mass spectrometry-based proteomics now enable the measurement of multiple properties for thousands of proteins, including their abundance, isoform expression, turnover rate, subcellular localization, post-translational modifications and interactions. Complementing these experimental developments are new data analysis, integration and visualization tools as well as data-sharing resources. Together, these advances in the multidimensional analysis of the proteome are transforming our understanding of various cellular and physiological processes.
    Original languageEnglish
    Pages (from-to)269-280
    Number of pages12
    JournalNature Reviews Molecular Cell Biology
    Issue number5
    Early online date10 Apr 2015
    Publication statusPublished - May 2015


    • Data integration
    • Data processing
    • Mass spectrometry
    • Proteomic analysis


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