Multidrug efflux in Gram-negative bacteria: structural modifications in active compounds leading to efflux pump avoidance

Keyphrases

• Gram-negative Bacteria 100%
• Efflux 100%
• Efflux Pump 100%
• Drug Efflux 100%
• Active Compounds 100%
• Structural Modification 100%
• Escherichia Coli 66%
• TolC 66%
• Low Permeability 33%
• New Drugs 33%
• LpxC 33%
• Rapid Development 33%
• Bioactivity 33%
• HyPer 33%
• Molecular Determinants 33%
• Physicochemical Features 33%
• Gram-negative 33%
• Drug Design 33%
• Molecular Features 33%
• Efflux System 33%
• Chemical Groups 33%
• Multidrug-resistant Infection 33%
• Gram-negative Cell Envelope 33%
• Drug Efflux Pump 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Effusion 100%
• Gram Negative Bacterium 100%
• Escherichia coli 22%
• Drug Development 11%
• Infection 11%

Biochemistry, Genetics and Molecular Biology

• Gram Negative Bacterium 100%
• Escherichia coli 66%
• Wild Type 33%
• Biological Activity 33%