Multifaceted transforming growth factor-beta (TGFβ) signalling in glioblastoma

Joanna L. Birch; Barry J. Coull; Lindsay C. Spender; Courtney Watt; Alice Willison; Nelofer Syed; Anthony J. Chalmers; M. Kismet Hossain-Ibrahim; Gareth J. Inman

doi:10.1016/j.cellsig.2020.109638

Multifaceted transforming growth factor-beta (TGFβ) signalling in glioblastoma

Joanna L. Birch, Barry J. Coull, Lindsay C. Spender, Courtney Watt, Alice Willison, Nelofer Syed, Anthony J. Chalmers, M. Kismet Hossain-Ibrahim, Gareth J. Inman (Lead / Corresponding author)

Research output: Contribution to journal › Review article › peer-review

25 Citations (Scopus)

Abstract

Glioblastoma (GBM) is an aggressive and devastating primary brain cancer which responds very poorly to treatment. The average survival time of patients is only 14–15 months from diagnosis so there is a clear and unmet need for the development of novel targeted therapies to improve patient outcomes. The multifunctional cytokine TGFβ plays fundamental roles in development, adult tissue homeostasis, tissue wound repair and immune responses. Dysfunction of TGFβ signalling has been implicated in both the development and progression of many tumour types including GBM, thereby potentially providing an actionable target for its treatment. This review will examine TGFβ signalling mechanisms and their role in the development and progression of GBM. The targeting of TGFβ signalling using a variety of approaches including the TGFβ binding protein Decorin will be highlighted as attractive therapeutic strategies.

Original language	English
Article number	109638
Number of pages	12
Journal	Cellular Signalling
Volume	72
Early online date	19 Apr 2020
DOIs	https://doi.org/10.1016/j.cellsig.2020.109638
Publication status	Published - Aug 2020

Keywords

Decorin
Glioblastoma
Transforming growth factor beta

ASJC Scopus subject areas

Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

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title = "Multifaceted transforming growth factor-beta (TGFβ) signalling in glioblastoma",

abstract = "Glioblastoma (GBM) is an aggressive and devastating primary brain cancer which responds very poorly to treatment. The average survival time of patients is only 14–15 months from diagnosis so there is a clear and unmet need for the development of novel targeted therapies to improve patient outcomes. The multifunctional cytokine TGFβ plays fundamental roles in development, adult tissue homeostasis, tissue wound repair and immune responses. Dysfunction of TGFβ signalling has been implicated in both the development and progression of many tumour types including GBM, thereby potentially providing an actionable target for its treatment. This review will examine TGFβ signalling mechanisms and their role in the development and progression of GBM. The targeting of TGFβ signalling using a variety of approaches including the TGFβ binding protein Decorin will be highlighted as attractive therapeutic strategies.",

keywords = "Decorin, Glioblastoma, Transforming growth factor beta",

author = "Birch, {Joanna L.} and Coull, {Barry J.} and Spender, {Lindsay C.} and Courtney Watt and Alice Willison and Nelofer Syed and Chalmers, {Anthony J.} and Hossain-Ibrahim, {M. Kismet} and Inman, {Gareth J.}",

note = "The authors acknowledge grants from Cancer Research UK (A29802) and Tenovus Tayside, UK.",

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doi = "10.1016/j.cellsig.2020.109638",

language = "English",

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AU - Birch, Joanna L.

AU - Coull, Barry J.

AU - Spender, Lindsay C.

AU - Watt, Courtney

AU - Willison, Alice

AU - Syed, Nelofer

AU - Chalmers, Anthony J.

AU - Hossain-Ibrahim, M. Kismet

AU - Inman, Gareth J.

N1 - The authors acknowledge grants from Cancer Research UK (A29802) and Tenovus Tayside, UK.

PY - 2020/8

Y1 - 2020/8

N2 - Glioblastoma (GBM) is an aggressive and devastating primary brain cancer which responds very poorly to treatment. The average survival time of patients is only 14–15 months from diagnosis so there is a clear and unmet need for the development of novel targeted therapies to improve patient outcomes. The multifunctional cytokine TGFβ plays fundamental roles in development, adult tissue homeostasis, tissue wound repair and immune responses. Dysfunction of TGFβ signalling has been implicated in both the development and progression of many tumour types including GBM, thereby potentially providing an actionable target for its treatment. This review will examine TGFβ signalling mechanisms and their role in the development and progression of GBM. The targeting of TGFβ signalling using a variety of approaches including the TGFβ binding protein Decorin will be highlighted as attractive therapeutic strategies.

AB - Glioblastoma (GBM) is an aggressive and devastating primary brain cancer which responds very poorly to treatment. The average survival time of patients is only 14–15 months from diagnosis so there is a clear and unmet need for the development of novel targeted therapies to improve patient outcomes. The multifunctional cytokine TGFβ plays fundamental roles in development, adult tissue homeostasis, tissue wound repair and immune responses. Dysfunction of TGFβ signalling has been implicated in both the development and progression of many tumour types including GBM, thereby potentially providing an actionable target for its treatment. This review will examine TGFβ signalling mechanisms and their role in the development and progression of GBM. The targeting of TGFβ signalling using a variety of approaches including the TGFβ binding protein Decorin will be highlighted as attractive therapeutic strategies.

KW - Decorin

KW - Glioblastoma

KW - Transforming growth factor beta

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U2 - 10.1016/j.cellsig.2020.109638

DO - 10.1016/j.cellsig.2020.109638

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SN - 0898-6568

VL - 72

JO - Cellular Signalling

JF - Cellular Signalling

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ER -

Multifaceted transforming growth factor-beta (TGFβ) signalling in glioblastoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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