Multiphoton imaging with high peak power VECSELs

Shamil Mirkhanov, Adrian H. Quarterman, Samuel Swift, Bavishna B. Praveen, Conor J C Smyth, Keith G. Wilcox

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)


Multiphoton imaging (MMPI) has become one of thee key non-invasive light microscopy techniques. This technique allows deep tissue imaging with high resolution and less photo-damage than conventional confocal microscopy. MPI is type of laser-scanning microscopy that employs localized nonlinear excitation, so that fluorescence is excited only with is scanned focal volume. For many years, Ti: sapphire femtosecond lasers have been the leading light sources for MPI applications. However, recent developments in laser sources and new types of fluorophores indicate that longer wavelength excitation could be a good alternative for these applications. Mode-locked VECSEELs have the potential to be low cost, compact light sources for MPI systems, with the additional advantage of broad wavelength coverage through use of different semiconductor material systems. Here, we use a femtosecond fibber laser to investigate the effect average power and repetition rate has on MPI image quality, to allow us to optimize our mode-locked VVECSELs for MPI.

Original languageEnglish
Title of host publicationVertical External Cavity Surface Emitting Lasers (VECSELs) VI
EditorsKeith G. Wilcox
Place of PublicationSan Francisco
PublisherSPIE-International Society for Optical Engineering
ISBN (Electronic)9781628419696
Publication statusPublished - 10 Mar 2016
EventSPIE Photonics West 2016: Vertical External Cavity Surface Emitting Lasers (VECSELs) VI - The Moscone Center, San Francisco, United States
Duration: 15 Feb 201616 Feb 2016 (Link to Conference details)


ConferenceSPIE Photonics West 2016
Country/TerritoryUnited States
CitySan Francisco
Internet address


  • Femtosecond Lasers
  • Multiphoton Imaging
  • Multiphoton microscopy
  • optically pumped semiconducto laser

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Applied Mathematics


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