Multiple roles for protein palmitoylation in plants

Piers A Hemsley, Claire S Grierson

    Research output: Contribution to journalReview article

    49 Citations (Scopus)

    Abstract

    Palmitoylation, more correctly known as S-acylation, aids in the regulation of cellular functions including stress response, disease resistance, hormone signalling, cell polarisation, cell expansion and cytoskeletal organization. S-acylation is the reversible addition of fatty acids to proteins, which increases their membrane affinity. Membrane-protein interactions are important for signalling complex formation and signal propagation, protein sequestration and segregation, protein stability, and maintaining polarity within the cell. S-acylation is a dynamic modification that modulates the activity and membrane association of many signalling molecules, including ROP GTPases, heterotrimeric G-proteins and calcium-sensing kinases. Recent advances in methods to study S-acylation are permitting an in-depth examination of its function in plants.
    Original languageEnglish
    Pages (from-to)295-302
    Number of pages8
    JournalTrends in Plant Science
    Volume13
    Issue number6
    DOIs
    Publication statusPublished - Jun 2008

    Fingerprint

    acylation
    proteins
    guanosinetriphosphatase
    cells
    G-proteins
    membrane proteins
    disease resistance
    stress response
    phosphotransferases (kinases)
    hormones
    fatty acids
    calcium
    palmitoylation
    methodology

    Cite this

    Hemsley, Piers A ; Grierson, Claire S. / Multiple roles for protein palmitoylation in plants. In: Trends in Plant Science. 2008 ; Vol. 13, No. 6. pp. 295-302.
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    Multiple roles for protein palmitoylation in plants. / Hemsley, Piers A; Grierson, Claire S.

    In: Trends in Plant Science, Vol. 13, No. 6, 06.2008, p. 295-302.

    Research output: Contribution to journalReview article

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    AU - Hemsley, Piers A

    AU - Grierson, Claire S

    PY - 2008/6

    Y1 - 2008/6

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    AB - Palmitoylation, more correctly known as S-acylation, aids in the regulation of cellular functions including stress response, disease resistance, hormone signalling, cell polarisation, cell expansion and cytoskeletal organization. S-acylation is the reversible addition of fatty acids to proteins, which increases their membrane affinity. Membrane-protein interactions are important for signalling complex formation and signal propagation, protein sequestration and segregation, protein stability, and maintaining polarity within the cell. S-acylation is a dynamic modification that modulates the activity and membrane association of many signalling molecules, including ROP GTPases, heterotrimeric G-proteins and calcium-sensing kinases. Recent advances in methods to study S-acylation are permitting an in-depth examination of its function in plants.

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    DO - 10.1016/j.tplants.2008.04.006

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