Multiple roles for protein palmitoylation in plants

Piers A Hemsley; Claire S Grierson

doi:10.1016/j.tplants.2008.04.006

Multiple roles for protein palmitoylation in plants

Piers A Hemsley
, Claire S Grierson

Research output: Contribution to journal › Review article › peer-review

78 Citations (Scopus)

Abstract

Palmitoylation, more correctly known as S-acylation, aids in the regulation of cellular functions including stress response, disease resistance, hormone signalling, cell polarisation, cell expansion and cytoskeletal organization. S-acylation is the reversible addition of fatty acids to proteins, which increases their membrane affinity. Membrane-protein interactions are important for signalling complex formation and signal propagation, protein sequestration and segregation, protein stability, and maintaining polarity within the cell. S-acylation is a dynamic modification that modulates the activity and membrane association of many signalling molecules, including ROP GTPases, heterotrimeric G-proteins and calcium-sensing kinases. Recent advances in methods to study S-acylation are permitting an in-depth examination of its function in plants.

Original language	English
Pages (from-to)	295-302
Number of pages	8
Journal	Trends in Plant Science
Volume	13
Issue number	6
DOIs	https://doi.org/10.1016/j.tplants.2008.04.006
Publication status	Published - Jun 2008

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SDG 3 Good Health and Well-being

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10.1016/j.tplants.2008.04.006

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title = "Multiple roles for protein palmitoylation in plants",

abstract = "Palmitoylation, more correctly known as S-acylation, aids in the regulation of cellular functions including stress response, disease resistance, hormone signalling, cell polarisation, cell expansion and cytoskeletal organization. S-acylation is the reversible addition of fatty acids to proteins, which increases their membrane affinity. Membrane-protein interactions are important for signalling complex formation and signal propagation, protein sequestration and segregation, protein stability, and maintaining polarity within the cell. S-acylation is a dynamic modification that modulates the activity and membrane association of many signalling molecules, including ROP GTPases, heterotrimeric G-proteins and calcium-sensing kinases. Recent advances in methods to study S-acylation are permitting an in-depth examination of its function in plants.",

author = "Hemsley, \{Piers A\} and Grierson, \{Claire S\}",

year = "2008",

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doi = "10.1016/j.tplants.2008.04.006",

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journal = "Trends in Plant Science",

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AU - Hemsley, Piers A

AU - Grierson, Claire S

PY - 2008/6

Y1 - 2008/6

N2 - Palmitoylation, more correctly known as S-acylation, aids in the regulation of cellular functions including stress response, disease resistance, hormone signalling, cell polarisation, cell expansion and cytoskeletal organization. S-acylation is the reversible addition of fatty acids to proteins, which increases their membrane affinity. Membrane-protein interactions are important for signalling complex formation and signal propagation, protein sequestration and segregation, protein stability, and maintaining polarity within the cell. S-acylation is a dynamic modification that modulates the activity and membrane association of many signalling molecules, including ROP GTPases, heterotrimeric G-proteins and calcium-sensing kinases. Recent advances in methods to study S-acylation are permitting an in-depth examination of its function in plants.

AB - Palmitoylation, more correctly known as S-acylation, aids in the regulation of cellular functions including stress response, disease resistance, hormone signalling, cell polarisation, cell expansion and cytoskeletal organization. S-acylation is the reversible addition of fatty acids to proteins, which increases their membrane affinity. Membrane-protein interactions are important for signalling complex formation and signal propagation, protein sequestration and segregation, protein stability, and maintaining polarity within the cell. S-acylation is a dynamic modification that modulates the activity and membrane association of many signalling molecules, including ROP GTPases, heterotrimeric G-proteins and calcium-sensing kinases. Recent advances in methods to study S-acylation are permitting an in-depth examination of its function in plants.

U2 - 10.1016/j.tplants.2008.04.006

DO - 10.1016/j.tplants.2008.04.006

M3 - Review article

C2 - 18501662

SN - 1360-1385

VL - 13

SP - 295

EP - 302

JO - Trends in Plant Science

JF - Trends in Plant Science

IS - 6

ER -

Multiple roles for protein palmitoylation in plants

Abstract

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