Multispectral monitoring of fluorescence during ALA-PDT of superficial skin cancers

J. Hewett, V. Nadeau, J. Ferguson, H. Moseley, S. Ibbotson, L. Brancaleon, D. Birkin, W. Sibbett, M. Padgett

    Research output: Contribution to journalArticlepeer-review


    We present a simple fluorescence imaging system for use in the demarcation and monitoring of skin cancers. The imaging system simultaneously acquires four spectrally specific images at 635, 600, 540 and 400nm. The incorporation of an image intensifier, coupled with high speed image processing gives video update rates. The integrated light source is based on low cost fluorescent bulbs, shaped to fit around the lens and phosphor coated to give a peak emission near 400nm, matched to the absorption maximum of PpIX. We apply this system to monitoring the fluorescence of the PpIX photosensitiser before during and after ALA based PDT.

    Original languageEnglish
    Pages (from-to)68-72
    Number of pages5
    JournalProceedings of SPIE-The International Society for Optical Engineering
    Publication statusPublished - 9 Apr 2001


    • 5-aminolaevulinic acid
    • Fluorescence imaging
    • Multispectral imaging
    • Photodetection

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Condensed Matter Physics
    • Computer Science Applications
    • Applied Mathematics
    • Electrical and Electronic Engineering


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