Multispectral monitoring of fluorescence during ALA-PDT of superficial skin cancers

J. Hewett; V. Nadeau; J. Ferguson; H. Moseley; S. Ibbotson; L. Brancaleon; D. Birkin; W. Sibbett; M. Padgett

doi:10.1117/12.424437

Multispectral monitoring of fluorescence during ALA-PDT of superficial skin cancers

J. Hewett
, V. Nadeau
, J. Ferguson
, H. Moseley
, S. Ibbotson
, L. Brancaleon
, D. Birkin
, W. Sibbett
, M. Padgett

Research output: Contribution to journal › Article › peer-review

Abstract

We present a simple fluorescence imaging system for use in the demarcation and monitoring of skin cancers. The imaging system simultaneously acquires four spectrally specific images at 635, 600, 540 and 400nm. The incorporation of an image intensifier, coupled with high speed image processing gives video update rates. The integrated light source is based on low cost fluorescent bulbs, shaped to fit around the lens and phosphor coated to give a peak emission near 400nm, matched to the absorption maximum of PpIX. We apply this system to monitoring the fluorescence of the PpIX photosensitiser before during and after ALA based PDT.

Original language	English
Pages (from-to)	68-72
Number of pages	5
Journal	Proceedings of SPIE-The International Society for Optical Engineering
Volume	4248
DOIs	https://doi.org/10.1117/12.424437
Publication status	Published - 9 Apr 2001

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

5-aminolaevulinic acid
Fluorescence imaging
Multispectral imaging
Photodetection

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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10.1117/12.424437

Cite this

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title = "Multispectral monitoring of fluorescence during ALA-PDT of superficial skin cancers",

abstract = "We present a simple fluorescence imaging system for use in the demarcation and monitoring of skin cancers. The imaging system simultaneously acquires four spectrally specific images at 635, 600, 540 and 400nm. The incorporation of an image intensifier, coupled with high speed image processing gives video update rates. The integrated light source is based on low cost fluorescent bulbs, shaped to fit around the lens and phosphor coated to give a peak emission near 400nm, matched to the absorption maximum of PpIX. We apply this system to monitoring the fluorescence of the PpIX photosensitiser before during and after ALA based PDT.",

keywords = "5-aminolaevulinic acid, Fluorescence imaging, Multispectral imaging, Photodetection",

author = "J. Hewett and V. Nadeau and J. Ferguson and H. Moseley and S. Ibbotson and L. Brancaleon and D. Birkin and W. Sibbett and M. Padgett",

year = "2001",

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doi = "10.1117/12.424437",

language = "English",

volume = "4248",

pages = "68--72",

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TY - JOUR

T1 - Multispectral monitoring of fluorescence during ALA-PDT of superficial skin cancers

AU - Hewett, J.

AU - Nadeau, V.

AU - Ferguson, J.

AU - Moseley, H.

AU - Ibbotson, S.

AU - Brancaleon, L.

AU - Birkin, D.

AU - Sibbett, W.

AU - Padgett, M.

PY - 2001/4/9

Y1 - 2001/4/9

N2 - We present a simple fluorescence imaging system for use in the demarcation and monitoring of skin cancers. The imaging system simultaneously acquires four spectrally specific images at 635, 600, 540 and 400nm. The incorporation of an image intensifier, coupled with high speed image processing gives video update rates. The integrated light source is based on low cost fluorescent bulbs, shaped to fit around the lens and phosphor coated to give a peak emission near 400nm, matched to the absorption maximum of PpIX. We apply this system to monitoring the fluorescence of the PpIX photosensitiser before during and after ALA based PDT.

AB - We present a simple fluorescence imaging system for use in the demarcation and monitoring of skin cancers. The imaging system simultaneously acquires four spectrally specific images at 635, 600, 540 and 400nm. The incorporation of an image intensifier, coupled with high speed image processing gives video update rates. The integrated light source is based on low cost fluorescent bulbs, shaped to fit around the lens and phosphor coated to give a peak emission near 400nm, matched to the absorption maximum of PpIX. We apply this system to monitoring the fluorescence of the PpIX photosensitiser before during and after ALA based PDT.

KW - 5-aminolaevulinic acid

KW - Fluorescence imaging

KW - Multispectral imaging

KW - Photodetection

UR - https://www.scopus.com/pages/publications/0034930504

U2 - 10.1117/12.424437

DO - 10.1117/12.424437

M3 - Article

AN - SCOPUS:0034930504

SN - 0277-786X

VL - 4248

SP - 68

EP - 72

JO - Proceedings of SPIE-The International Society for Optical Engineering

JF - Proceedings of SPIE-The International Society for Optical Engineering

ER -

Multispectral monitoring of fluorescence during ALA-PDT of superficial skin cancers

Abstract

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Keywords

ASJC Scopus subject areas

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