The group of reticulate pigmentary disorders includes the rare autosomal dominant Dowling-Degos disease (DDD) and Galli-Galli disease (GGD;.OMIM 179850, OMIM 615327, OMIM 615696). (1) In light of substantial clinical, histological and mutational overlap between GGD and DDD they are considered to belong to the same entity. (2-3) Mutations in KRT5 (encoding keratin 5) have been associated with GGD/DDD since 2006. (2-5) With the development of whole exome sequencing (WES), mutations in POFUT1 (encoding protein O-fucosyltransferase 1) (6-7) and POGLUT1 (encoding protein O-glucosyltransferase 1) (8) have been shown to underlie some cases of GGD/DDD. We report mutations in POGLUT1 in 3 families of European ancestry. This article is protected by copyright. All rights reserved.