Mutations of APC, K-ras, and p53 are associated with specific chromosomal aberrations in colorectal adenocarcinomas

Amy Leslie, Norman R. Pratt, Karen Gillespie, Mark Sales, Neil M. Kernohan, Gillian Smith, C. Roland Wolf, Francis A. Carey, Robert J. C. Steele

    Research output: Contribution to journalArticle

    69 Citations (Scopus)

    Abstract

    It is widely accepted that both large-scale chromosomal abnormalities and mutation of specific genes, such as APC, K-ras, and/or p53, occur in the majority of colorectal adenocarcinomas. Whether or not a relationship exists between these different forms of genetic abnormalities was previously unknown. Using comparative genomic hybridization and mutational analysis of APC, K-ras, and p53 to evaluate 50 colorectal adenocarcinomas, we have shown that mutation of p53 is significantly associated with gain of 20q, 13q, and 8q and loss of 18q (P = 0.000, 0.02, 0.044, and 0.001, respectively). Conversely, APC mutation did not associate with any of the above-mentioned aberrations but did associate significantly with gain of 7p (P = 0.01). Gain of chromosomal arm 12p, although a less common aberration, was significantly associated with K-ras mutation (P = 0.011). The associations we have described should refine the search for candidate genes underlying chromosomal aberrations and assist in the definition of distinct pathways in colorectal tumorigenesis.

    Original languageEnglish
    Pages (from-to)4656-4661
    Number of pages6
    JournalCancer Research
    Volume63
    Issue number15
    Publication statusPublished - Aug 2003

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