The structure of fucosylated derivatives of N-acetyl lactosamine expressed during human renal development has been studied by the combined use of monoclonal antibodies and glycosyl hydrolases. LeX is expressed on the ureteric bud ampulla carried N-linked on a glycoprotein. It is also present in the proximal tubule as a ganglioside. H-Type II substance is expressed on the endothelium of the developing renal vasculature. It is also carried N-linked to a glycoprotein. These regulated changes in the cell surface carbohydrate expression are important in understanding cell interactions and receptor systems during renal development.
|Number of pages||10|
|Journal||Journal of Anatomy|
|Publication status||Published - 1990|
Fleming, S. (1990). N-linked oligosaccharides during human renal organogenesis. Journal of Anatomy, 170, 151-160. http://www.scopus.com/results/results.url?sort=plf-f&src=s&st1=N-linked+oligosaccharides+during+human+renal+organogenesis&sid=3E474EBD3E949E93DC775820D5BA1F57.y7ESLndDIsN8cE7qwvy6w%3a90&sot=b&sdt=b&sl=73&s=TITLE-ABS-KEY%28N-linked+oligosaccharides+during+human+renal+organogenesis%29&origin=searchbasic&txGid=3E474EBD3E949E93DC775820D5BA1F57.y7ESLndDIsN8cE7qwvy6w%3a9