@article{ae6dd3ee48f44860b8e3d077a3c38d6a,
title = "N6-methyladenosine RNA modification promotes viral genomic RNA stability and infection",
abstract = "Molecular manipulation of susceptibility (S) genes that are antipodes to resistance (R) genes has been adopted as an alternative strategy for controlling crop diseases. Here, we show the S gene encoding Triticum aestivum m6A methyltransferase B (TaMTB) is identified by a genome-wide association study and subsequently shown to be a positive regulator for wheat yellow mosaic virus (WYMV) infection. TaMTB is localized in the nucleus, is translocated into the cytoplasmic aggregates by binding to WYMV NIb to upregulate the m6A level of WYMV RNA1 and stabilize the viral RNA, thus promoting viral infection. A natural mutant allele TaMTB-SNP176C is found to confer an enhanced susceptibility to WYMV infection through genetic variation analysis on 243 wheat varieties. Our discovery highlights this allele can be a useful target for the molecular wheat breeding in the future.",
author = "Tianye Zhang and Chaonan Shi and Haichao Hu and Zhuo Zhang and Ziqiong Wang and Zhiqing Chen and Huimin Feng and Peng Liu and Jun Guo and Qisen Lu and Kaili Zhong and Chen, {Zhi Hui} and Jiaqian Liu and Jiancheng Yu and Jianping Chen and Jian Yang and Feng Chen",
note = "Funding Information: This work was supported by China Agriculture Research System from the Ministry of Agriculture of the P.R. China (CARS-03), National Natural Science Foundation (31861143008), Ningbo Science and Technology Innovation 2025 Major Project, China (Q21C140013), National Natural Science Foundation of China (Grant Nos. U20A20121 and 61971248), and K.C. Wong Magna Funding Ningbo University. Funding Information: We wish to thank Dr. Zhensheng Kang (Northwest Agricultural and Forestry University, Yangling, Shaanxi Province, China) for providing the BSMV-based VIGS vector. We also thank Dr. Yule Liu for his help and suggestions to this article. This work was supported by China Agriculture Research System from the Ministry of Agriculture of the P.R. China (CARS-03), National Natural Science Foundation (31861143008), Ningbo Science and Technology Innovation 2025 Major Project, China (Q21C140013), National Natural Science Foundation of China (Grant Nos. U20A20121 and 61971248), and K.C. Wong Magna Funding Ningbo University. Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
month = dec,
doi = "10.1038/s41467-022-34362-x",
language = "English",
volume = "13",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}