NADPH oxidase signaling and cardiac myocyte function

Ashwin Akki, Min Zhang, Colin Murdoch, Alison Brewer, Ajay M. Shah (Lead / Corresponding author)

Research output: Contribution to journalReview article

94 Citations (Scopus)

Abstract

The NADPH oxidase family of enzymes has emerged as a major source of reactive oxygen species (ROS) that is important in diverse cellular functions including anti-microbial defence, inflammation and redox signaling. Of the five known NADPH oxidase isoforms, several are expressed in cardiovascular cells where they are involved in physiological and pathological processes such as the regulation of vascular tone, cell growth, migration, proliferation, hypertrophy, apoptosis and matrix deposition. This article reviews current knowledge regarding the role of NADPH oxidases in cardiomyocyte function in health and disease.
Original languageEnglish
Pages (from-to)15-22
Number of pages8
JournalJournal of Molecular and Cellular Cardiology
Volume47
Issue number1
DOIs
Publication statusPublished - Jul 2009

Fingerprint

NADPH Oxidase
Cardiac Myocytes
Physiological Phenomena
Pathologic Processes
Hypertrophy
Oxidation-Reduction
Cell Movement
Blood Vessels
Reactive Oxygen Species
Protein Isoforms
Apoptosis
Inflammation
Health
Enzymes
Growth

Keywords

  • NADPH oxidase
  • Redox
  • remodeling
  • hypertrophy
  • contraction
  • signaling
  • cardiac myocytes

Cite this

Akki, Ashwin ; Zhang, Min ; Murdoch, Colin ; Brewer, Alison ; Shah, Ajay M. / NADPH oxidase signaling and cardiac myocyte function. In: Journal of Molecular and Cellular Cardiology. 2009 ; Vol. 47, No. 1. pp. 15-22.
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NADPH oxidase signaling and cardiac myocyte function. / Akki, Ashwin; Zhang, Min; Murdoch, Colin; Brewer, Alison; Shah, Ajay M. (Lead / Corresponding author).

In: Journal of Molecular and Cellular Cardiology, Vol. 47, No. 1, 07.2009, p. 15-22.

Research output: Contribution to journalReview article

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T1 - NADPH oxidase signaling and cardiac myocyte function

AU - Akki, Ashwin

AU - Zhang, Min

AU - Murdoch, Colin

AU - Brewer, Alison

AU - Shah, Ajay M.

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N2 - The NADPH oxidase family of enzymes has emerged as a major source of reactive oxygen species (ROS) that is important in diverse cellular functions including anti-microbial defence, inflammation and redox signaling. Of the five known NADPH oxidase isoforms, several are expressed in cardiovascular cells where they are involved in physiological and pathological processes such as the regulation of vascular tone, cell growth, migration, proliferation, hypertrophy, apoptosis and matrix deposition. This article reviews current knowledge regarding the role of NADPH oxidases in cardiomyocyte function in health and disease.

AB - The NADPH oxidase family of enzymes has emerged as a major source of reactive oxygen species (ROS) that is important in diverse cellular functions including anti-microbial defence, inflammation and redox signaling. Of the five known NADPH oxidase isoforms, several are expressed in cardiovascular cells where they are involved in physiological and pathological processes such as the regulation of vascular tone, cell growth, migration, proliferation, hypertrophy, apoptosis and matrix deposition. This article reviews current knowledge regarding the role of NADPH oxidases in cardiomyocyte function in health and disease.

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KW - Redox

KW - remodeling

KW - hypertrophy

KW - contraction

KW - signaling

KW - cardiac myocytes

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DO - 10.1016/j.yjmcc.2009.04.004

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