NADPH oxidase signaling and cardiac myocyte function

Ashwin Akki, Min Zhang, Colin Murdoch, Alison Brewer, Ajay M. Shah (Lead / Corresponding author)

    Research output: Contribution to journalReview articlepeer-review

    111 Citations (Scopus)

    Abstract

    The NADPH oxidase family of enzymes has emerged as a major source of reactive oxygen species (ROS) that is important in diverse cellular functions including anti-microbial defence, inflammation and redox signaling. Of the five known NADPH oxidase isoforms, several are expressed in cardiovascular cells where they are involved in physiological and pathological processes such as the regulation of vascular tone, cell growth, migration, proliferation, hypertrophy, apoptosis and matrix deposition. This article reviews current knowledge regarding the role of NADPH oxidases in cardiomyocyte function in health and disease.
    Original languageEnglish
    Pages (from-to)15-22
    Number of pages8
    JournalJournal of Molecular and Cellular Cardiology
    Volume47
    Issue number1
    DOIs
    Publication statusPublished - Jul 2009

    Keywords

    • NADPH oxidase
    • Redox
    • remodeling
    • hypertrophy
    • contraction
    • signaling
    • cardiac myocytes

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