Nanotechnology in multimodal theranostic capsule endoscopy

S. Cochran; T. W. Button; B. F. Cox; D. R. S. Cumming; D. Gourevich; H. S. Lay; H. Mulvana; I. S. Nathke; F. Stewart

doi:10.1109/NANO.2017.8117439

Nanotechnology in multimodal theranostic capsule endoscopy

S. Cochran (Lead / Corresponding author), T. W. Button, B. F. Cox, D. R. S. Cumming, D. Gourevich, H. S. Lay, H. Mulvana, I. S. Nathke, F. Stewart

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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Abstract

Video capsule endoscopy (VCE) has become a clinically accepted diagnostic modality in the last 20 years and has established a technological roadmap for other capsule endoscopy (CE) devices, incorporating microscale technology, a local power supply and wireless communication. However, VCE does not provide a therapeutic function and research in therapeutic capsule endoscopy (TCE) has been limited. This paper proposes a new route towards viable TCE based on multiple CE devices including essential nanoscale components. A first device is used for multimodal diagnosis, with quantitative microultrasound as a complement to video imaging. Ultrasound-enhanced fluorescent marking of sites of pathology allows follow-up with a second device for therapy. This is based on fluorescence imaging and ultrasound-mediated targeted drug delivery. Subsequent treatment verification and monitoring with a third device exploits the minimally invasive nature of CE. Clinical implementation of a complete patient pathway remains the subject of research but several key components have been prepared in early prototype form. These are described, along with gaps that remain to be filled.

Original language	English
Title of host publication	2017 IEEE 17th International Conference on Nanotechnology, NANO 2017
Place of Publication	United States
Publisher	IEEE
Pages	434-435
Number of pages	2
ISBN (Electronic)	9781509030286
DOIs	https://doi.org/10.1109/NANO.2017.8117439
Publication status	Published - 23 Nov 2017
Event	17th IEEE International Conference on Nanotechnology, NANO 2017 - Pittsburgh, United States Duration: 25 Jul 2017 → 28 Jul 2017

Conference

Conference	17th IEEE International Conference on Nanotechnology, NANO 2017
Country/Territory	United States
City	Pittsburgh
Period	25/07/17 → 28/07/17

Keywords

Drugs
Nanoscale devices
Fluorescence
Endoscopes
Imaging
Ultrasonic imaging

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Surfaces, Coatings and Films
Electrical and Electronic Engineering

Access to Document

10.1109/NANO.2017.8117439

Author Accepted Manuscript
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Accepted author manuscript, 249 KB

Sonopill: Minimally Invasive Gastrointestinal Diagnosis and Therapy (Joint with University of Glasgow & Heriot Watt University)
Cochran, S. (Investigator), Corner, G. (Investigator), Cuschieri, A. (Investigator), Nathke, I. (Investigator) & Steele, B. (Investigator)
Engineering and Physical Sciences Research Council
27/05/13 → 14/12/18
Project: Research

Cite this

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title = "Nanotechnology in multimodal theranostic capsule endoscopy",

abstract = "Video capsule endoscopy (VCE) has become a clinically accepted diagnostic modality in the last 20 years and has established a technological roadmap for other capsule endoscopy (CE) devices, incorporating microscale technology, a local power supply and wireless communication. However, VCE does not provide a therapeutic function and research in therapeutic capsule endoscopy (TCE) has been limited. This paper proposes a new route towards viable TCE based on multiple CE devices including essential nanoscale components. A first device is used for multimodal diagnosis, with quantitative microultrasound as a complement to video imaging. Ultrasound-enhanced fluorescent marking of sites of pathology allows follow-up with a second device for therapy. This is based on fluorescence imaging and ultrasound-mediated targeted drug delivery. Subsequent treatment verification and monitoring with a third device exploits the minimally invasive nature of CE. Clinical implementation of a complete patient pathway remains the subject of research but several key components have been prepared in early prototype form. These are described, along with gaps that remain to be filled.",

keywords = "Drugs, Nanoscale devices, Fluorescence, Endoscopes, Imaging, Ultrasonic imaging",

author = "S. Cochran and Button, {T. W.} and Cox, {B. F.} and Cumming, {D. R. S.} and D. Gourevich and Lay, {H. S.} and H. Mulvana and Nathke, {I. S.} and F. Stewart",

note = "This research is supported by the UK EPSRC Sonopill Programme, ref. GR/K034537. It previously drew support from the EU Nanoporation project, ref. 230674. ; 17th IEEE International Conference on Nanotechnology, NANO 2017 ; Conference date: 25-07-2017 Through 28-07-2017",

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month = nov,

day = "23",

doi = "10.1109/NANO.2017.8117439",

language = "English",

pages = "434--435",

booktitle = "2017 IEEE 17th International Conference on Nanotechnology, NANO 2017",

publisher = "IEEE",

}

Cochran, S, Button, TW, Cox, BF, Cumming, DRS, Gourevich, D, Lay, HS, Mulvana, H, Nathke, IS & Stewart, F 2017, Nanotechnology in multimodal theranostic capsule endoscopy. in 2017 IEEE 17th International Conference on Nanotechnology, NANO 2017., 8117439, IEEE, United States, pp. 434-435, 17th IEEE International Conference on Nanotechnology, NANO 2017, Pittsburgh, United States, 25/07/17. https://doi.org/10.1109/NANO.2017.8117439

TY - GEN

T1 - Nanotechnology in multimodal theranostic capsule endoscopy

AU - Cochran, S.

AU - Button, T. W.

AU - Cox, B. F.

AU - Cumming, D. R. S.

AU - Gourevich, D.

AU - Lay, H. S.

AU - Mulvana, H.

AU - Nathke, I. S.

AU - Stewart, F.

N1 - This research is supported by the UK EPSRC Sonopill Programme, ref. GR/K034537. It previously drew support from the EU Nanoporation project, ref. 230674.

PY - 2017/11/23

Y1 - 2017/11/23

N2 - Video capsule endoscopy (VCE) has become a clinically accepted diagnostic modality in the last 20 years and has established a technological roadmap for other capsule endoscopy (CE) devices, incorporating microscale technology, a local power supply and wireless communication. However, VCE does not provide a therapeutic function and research in therapeutic capsule endoscopy (TCE) has been limited. This paper proposes a new route towards viable TCE based on multiple CE devices including essential nanoscale components. A first device is used for multimodal diagnosis, with quantitative microultrasound as a complement to video imaging. Ultrasound-enhanced fluorescent marking of sites of pathology allows follow-up with a second device for therapy. This is based on fluorescence imaging and ultrasound-mediated targeted drug delivery. Subsequent treatment verification and monitoring with a third device exploits the minimally invasive nature of CE. Clinical implementation of a complete patient pathway remains the subject of research but several key components have been prepared in early prototype form. These are described, along with gaps that remain to be filled.

AB - Video capsule endoscopy (VCE) has become a clinically accepted diagnostic modality in the last 20 years and has established a technological roadmap for other capsule endoscopy (CE) devices, incorporating microscale technology, a local power supply and wireless communication. However, VCE does not provide a therapeutic function and research in therapeutic capsule endoscopy (TCE) has been limited. This paper proposes a new route towards viable TCE based on multiple CE devices including essential nanoscale components. A first device is used for multimodal diagnosis, with quantitative microultrasound as a complement to video imaging. Ultrasound-enhanced fluorescent marking of sites of pathology allows follow-up with a second device for therapy. This is based on fluorescence imaging and ultrasound-mediated targeted drug delivery. Subsequent treatment verification and monitoring with a third device exploits the minimally invasive nature of CE. Clinical implementation of a complete patient pathway remains the subject of research but several key components have been prepared in early prototype form. These are described, along with gaps that remain to be filled.

KW - Drugs

KW - Nanoscale devices

KW - Fluorescence

KW - Endoscopes

KW - Imaging

KW - Ultrasonic imaging

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DO - 10.1109/NANO.2017.8117439

M3 - Conference contribution

AN - SCOPUS:85041235558

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EP - 435

BT - 2017 IEEE 17th International Conference on Nanotechnology, NANO 2017

PB - IEEE

CY - United States

T2 - 17th IEEE International Conference on Nanotechnology, NANO 2017

Y2 - 25 July 2017 through 28 July 2017

ER -

Nanotechnology in multimodal theranostic capsule endoscopy

Abstract

Conference

Keywords

ASJC Scopus subject areas

Access to Document

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Projects

Sonopill: Minimally Invasive Gastrointestinal Diagnosis and Therapy (Joint with University of Glasgow & Heriot Watt University)

Cite this