Nanotechnology in multimodal theranostic capsule endoscopy

S. Cochran (Lead / Corresponding author), T. W. Button, B. F. Cox, D. R. S. Cumming, D. Gourevich, H. S. Lay, H. Mulvana, I. S. Nathke, F. Stewart

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Abstract

Video capsule endoscopy (VCE) has become a clinically accepted diagnostic modality in the last 20 years and has established a technological roadmap for other capsule endoscopy (CE) devices, incorporating microscale technology, a local power supply and wireless communication. However, VCE does not provide a therapeutic function and research in therapeutic capsule endoscopy (TCE) has been limited. This paper proposes a new route towards viable TCE based on multiple CE devices including essential nanoscale components. A first device is used for multimodal diagnosis, with quantitative microultrasound as a complement to video imaging. Ultrasound-enhanced fluorescent marking of sites of pathology allows follow-up with a second device for therapy. This is based on fluorescence imaging and ultrasound-mediated targeted drug delivery. Subsequent treatment verification and monitoring with a third device exploits the minimally invasive nature of CE. Clinical implementation of a complete patient pathway remains the subject of research but several key components have been prepared in early prototype form. These are described, along with gaps that remain to be filled.

Original languageEnglish
Title of host publication2017 IEEE 17th International Conference on Nanotechnology, NANO 2017
Place of PublicationUnited States
PublisherIEEE
Pages434-435
Number of pages2
ISBN (Electronic)9781509030286
DOIs
Publication statusPublished - 23 Nov 2017
Event17th IEEE International Conference on Nanotechnology, NANO 2017 - Pittsburgh, United States
Duration: 25 Jul 201728 Jul 2017

Conference

Conference17th IEEE International Conference on Nanotechnology, NANO 2017
Country/TerritoryUnited States
CityPittsburgh
Period25/07/1728/07/17

Keywords

  • Drugs
  • Nanoscale devices
  • Fluorescence
  • Endoscopes
  • Imaging
  • Ultrasonic imaging

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