Nanotechnology in multimodal theranostic capsule endoscopy

S. Cochran (Lead / Corresponding author), T. W. Button, B. F. Cox, D. R. S. Cumming, D. Gourevich, H. S. Lay, H. Mulvana, I. S. Nathke, F. Stewart

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

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    Abstract

    Video capsule endoscopy (VCE) has become a clinically accepted diagnostic modality in the last 20 years and has established a technological roadmap for other capsule endoscopy (CE) devices, incorporating microscale technology, a local power supply and wireless communication. However, VCE does not provide a therapeutic function and research in therapeutic capsule endoscopy (TCE) has been limited. This paper proposes a new route towards viable TCE based on multiple CE devices including essential nanoscale components. A first device is used for multimodal diagnosis, with quantitative microultrasound as a complement to video imaging. Ultrasound-enhanced fluorescent marking of sites of pathology allows follow-up with a second device for therapy. This is based on fluorescence imaging and ultrasound-mediated targeted drug delivery. Subsequent treatment verification and monitoring with a third device exploits the minimally invasive nature of CE. Clinical implementation of a complete patient pathway remains the subject of research but several key components have been prepared in early prototype form. These are described, along with gaps that remain to be filled.

    Original languageEnglish
    Title of host publication2017 IEEE 17th International Conference on Nanotechnology, NANO 2017
    Place of PublicationUnited States
    PublisherIEEE
    Pages434-435
    Number of pages2
    ISBN (Electronic)9781509030286
    DOIs
    Publication statusPublished - 23 Nov 2017
    Event17th IEEE International Conference on Nanotechnology, NANO 2017 - Pittsburgh, United States
    Duration: 25 Jul 201728 Jul 2017

    Conference

    Conference17th IEEE International Conference on Nanotechnology, NANO 2017
    Country/TerritoryUnited States
    CityPittsburgh
    Period25/07/1728/07/17

    Keywords

    • Drugs
    • Nanoscale devices
    • Fluorescence
    • Endoscopes
    • Imaging
    • Ultrasonic imaging

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Surfaces, Coatings and Films
    • Electrical and Electronic Engineering

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