National implementation of multi-parametric magnetic resonance imaging for prostate cancer detection – recommendations from a UK consensus meeting

Mrishta Brizmohun Appayya; Jim Adshead; Hashim U. Ahmed; Clare Allen; Alan Bainbridge; Tristan Barrett; Francesco Giganti; John Graham; Phil Haslam; Edward W. Johnston; Christof Kastner; Alexander P. S. Kirkham; Alexandra Lipton; Alan McNeill; Larissa Moniz; Caroline M. Moore; Ghulam Nabi; Anwar R. Padhani; Chris Parker; Amit Patel; Jacqueline Pursey; Jonathan Richenberg; John Staffurth; Jan van der Meulen; Darren Walls; Shonit Punwani

doi:10.1111/bju.14361

National implementation of multi-parametric magnetic resonance imaging for prostate cancer detection – recommendations from a UK consensus meeting

Mrishta Brizmohun Appayya, Jim Adshead, Hashim U. Ahmed, Clare Allen, Alan Bainbridge, Tristan Barrett, Francesco Giganti, John Graham, Phil Haslam, Edward W. Johnston, Christof Kastner, Alexander P. S. Kirkham, Alexandra Lipton, Alan McNeill, Larissa Moniz, Caroline M. Moore, Ghulam Nabi, Anwar R. Padhani, Chris Parker, Amit PatelJacqueline Pursey, Jonathan Richenberg, John Staffurth, Jan van der Meulen, Darren Walls, Shonit Punwani (Lead / Corresponding author)

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Abstract

Objectives: To identify areas of agreement and disagreement in the implementation of multi-parametric MRI (mpMRI) of the prostate in the diagnostic pathway.

Materials and Methods: Fifteen UK experts in prostate mpMRI and/or prostate cancer management across the UK (involving 9 NHS centres to provide for geographical spread) participated in a consensus meeting following the UCLA-RAND Appropriateness Method, and were moderated by an independent chair. The experts considered 354 items pertaining to who can request an mpMRI, prostate mpMRI protocol, reporting guidelines, training, quality assurance (QA) and patient management based on mpMRI levels of suspicion for cancer. Each item was rated for agreement on a 9-point scale. A panel median score of >/= 7 constituted 'agreement' for an item; for an item to reach 'consensus', a panel majority scoring was required.

Results: Consensus was reached on 59% of items (208/354); these were used to provide recommendations for the implementation of prostate mpMRI in the UK. Key findings include prostate mpMRI requests should be made in consultation with the urological team; mpMRI scanners should undergo quality assurance checks to guarantee consistently high diagnostic quality scans; scans should only be reported by trained and experienced radiologists to ensure that men with non-suspicious prostate mpMRI might consider avoiding an immediate biopsy.

Conclusions: Our consensus statements demonstrate a set of criteria that are required for the practical dissemination of consistently high quality prostate mpMRI as a diagnostic test prior to biopsy in men at risk.

Original language	English
Pages (from-to)	13-25
Number of pages	13
Journal	BJU International
Volume	122
Issue number	1
Early online date	26 Apr 2018
DOIs	https://doi.org/10.1111/bju.14361
Publication status	Published - 1 Jul 2018

Keywords

consensus methods
multi-parametric MRI
prostate cancer
recommendations

ASJC Scopus subject areas

Urology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Brizmohun Appayya, M., Adshead, J., Ahmed, H. U., Allen, C., Bainbridge, A., Barrett, T., Giganti, F., Graham, J., Haslam, P., Johnston, E. W., Kastner, C., Kirkham, A. P. S., Lipton, A., McNeill, A., Moniz, L., Moore, C. M., Nabi, G., Padhani, A. R., Parker, C., ... Punwani, S. (2018). National implementation of multi-parametric magnetic resonance imaging for prostate cancer detection – recommendations from a UK consensus meeting. BJU International, 122(1), 13-25. https://doi.org/10.1111/bju.14361

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title = "National implementation of multi-parametric magnetic resonance imaging for prostate cancer detection – recommendations from a UK consensus meeting",

abstract = "Objectives: To identify areas of agreement and disagreement in the implementation of multi-parametric MRI (mpMRI) of the prostate in the diagnostic pathway.Materials and Methods: Fifteen UK experts in prostate mpMRI and/or prostate cancer management across the UK (involving 9 NHS centres to provide for geographical spread) participated in a consensus meeting following the UCLA-RAND Appropriateness Method, and were moderated by an independent chair. The experts considered 354 items pertaining to who can request an mpMRI, prostate mpMRI protocol, reporting guidelines, training, quality assurance (QA) and patient management based on mpMRI levels of suspicion for cancer. Each item was rated for agreement on a 9-point scale. A panel median score of >/= 7 constituted 'agreement' for an item; for an item to reach 'consensus', a panel majority scoring was required.Results: Consensus was reached on 59% of items (208/354); these were used to provide recommendations for the implementation of prostate mpMRI in the UK. Key findings include prostate mpMRI requests should be made in consultation with the urological team; mpMRI scanners should undergo quality assurance checks to guarantee consistently high diagnostic quality scans; scans should only be reported by trained and experienced radiologists to ensure that men with non-suspicious prostate mpMRI might consider avoiding an immediate biopsy.Conclusions: Our consensus statements demonstrate a set of criteria that are required for the practical dissemination of consistently high quality prostate mpMRI as a diagnostic test prior to biopsy in men at risk.",

keywords = "consensus methods, multi-parametric MRI, prostate cancer, recommendations",

author = "{Brizmohun Appayya}, Mrishta and Jim Adshead and Ahmed, {Hashim U.} and Clare Allen and Alan Bainbridge and Tristan Barrett and Francesco Giganti and John Graham and Phil Haslam and Johnston, {Edward W.} and Christof Kastner and Kirkham, {Alexander P. S.} and Alexandra Lipton and Alan McNeill and Larissa Moniz and Moore, {Caroline M.} and Ghulam Nabi and Padhani, {Anwar R.} and Chris Parker and Amit Patel and Jacqueline Pursey and Jonathan Richenberg and John Staffurth and {van der Meulen}, Jan and Darren Walls and Shonit Punwani",

note = "MBA received funding support from Prostate Cancer UK and London Cancer. JvdM is partly supported by the NHS National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care North Thames. HUA is supported by the NIHR Imperial Biomedical Research Centre and the Wellcome Trust. SP receives funding support from the NIHR UCLH Biomedical Research Centre, London Cancer and the CRUK KCL/UCL Cancer Imaging Centre. ",

year = "2018",

month = jul,

day = "1",

doi = "10.1111/bju.14361",

language = "English",

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journal = "BJU International",

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Brizmohun Appayya, M, Adshead, J, Ahmed, HU, Allen, C, Bainbridge, A, Barrett, T, Giganti, F, Graham, J, Haslam, P, Johnston, EW, Kastner, C, Kirkham, APS, Lipton, A, McNeill, A, Moniz, L, Moore, CM, Nabi, G, Padhani, AR, Parker, C, Patel, A, Pursey, J, Richenberg, J, Staffurth, J, van der Meulen, J, Walls, D & Punwani, S 2018, 'National implementation of multi-parametric magnetic resonance imaging for prostate cancer detection – recommendations from a UK consensus meeting', BJU International, vol. 122, no. 1, pp. 13-25. https://doi.org/10.1111/bju.14361

TY - JOUR

T1 - National implementation of multi-parametric magnetic resonance imaging for prostate cancer detection – recommendations from a UK consensus meeting

AU - Brizmohun Appayya, Mrishta

AU - Adshead, Jim

AU - Ahmed, Hashim U.

AU - Allen, Clare

AU - Bainbridge, Alan

AU - Barrett, Tristan

AU - Giganti, Francesco

AU - Graham, John

AU - Haslam, Phil

AU - Johnston, Edward W.

AU - Kastner, Christof

AU - Kirkham, Alexander P. S.

AU - Lipton, Alexandra

AU - McNeill, Alan

AU - Moniz, Larissa

AU - Moore, Caroline M.

AU - Nabi, Ghulam

AU - Padhani, Anwar R.

AU - Parker, Chris

AU - Patel, Amit

AU - Pursey, Jacqueline

AU - Richenberg, Jonathan

AU - Staffurth, John

AU - van der Meulen, Jan

AU - Walls, Darren

AU - Punwani, Shonit

N1 - MBA received funding support from Prostate Cancer UK and London Cancer. JvdM is partly supported by the NHS National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care North Thames. HUA is supported by the NIHR Imperial Biomedical Research Centre and the Wellcome Trust. SP receives funding support from the NIHR UCLH Biomedical Research Centre, London Cancer and the CRUK KCL/UCL Cancer Imaging Centre.

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Objectives: To identify areas of agreement and disagreement in the implementation of multi-parametric MRI (mpMRI) of the prostate in the diagnostic pathway.Materials and Methods: Fifteen UK experts in prostate mpMRI and/or prostate cancer management across the UK (involving 9 NHS centres to provide for geographical spread) participated in a consensus meeting following the UCLA-RAND Appropriateness Method, and were moderated by an independent chair. The experts considered 354 items pertaining to who can request an mpMRI, prostate mpMRI protocol, reporting guidelines, training, quality assurance (QA) and patient management based on mpMRI levels of suspicion for cancer. Each item was rated for agreement on a 9-point scale. A panel median score of >/= 7 constituted 'agreement' for an item; for an item to reach 'consensus', a panel majority scoring was required.Results: Consensus was reached on 59% of items (208/354); these were used to provide recommendations for the implementation of prostate mpMRI in the UK. Key findings include prostate mpMRI requests should be made in consultation with the urological team; mpMRI scanners should undergo quality assurance checks to guarantee consistently high diagnostic quality scans; scans should only be reported by trained and experienced radiologists to ensure that men with non-suspicious prostate mpMRI might consider avoiding an immediate biopsy.Conclusions: Our consensus statements demonstrate a set of criteria that are required for the practical dissemination of consistently high quality prostate mpMRI as a diagnostic test prior to biopsy in men at risk.

AB - Objectives: To identify areas of agreement and disagreement in the implementation of multi-parametric MRI (mpMRI) of the prostate in the diagnostic pathway.Materials and Methods: Fifteen UK experts in prostate mpMRI and/or prostate cancer management across the UK (involving 9 NHS centres to provide for geographical spread) participated in a consensus meeting following the UCLA-RAND Appropriateness Method, and were moderated by an independent chair. The experts considered 354 items pertaining to who can request an mpMRI, prostate mpMRI protocol, reporting guidelines, training, quality assurance (QA) and patient management based on mpMRI levels of suspicion for cancer. Each item was rated for agreement on a 9-point scale. A panel median score of >/= 7 constituted 'agreement' for an item; for an item to reach 'consensus', a panel majority scoring was required.Results: Consensus was reached on 59% of items (208/354); these were used to provide recommendations for the implementation of prostate mpMRI in the UK. Key findings include prostate mpMRI requests should be made in consultation with the urological team; mpMRI scanners should undergo quality assurance checks to guarantee consistently high diagnostic quality scans; scans should only be reported by trained and experienced radiologists to ensure that men with non-suspicious prostate mpMRI might consider avoiding an immediate biopsy.Conclusions: Our consensus statements demonstrate a set of criteria that are required for the practical dissemination of consistently high quality prostate mpMRI as a diagnostic test prior to biopsy in men at risk.

KW - consensus methods

KW - multi-parametric MRI

KW - prostate cancer

KW - recommendations

U2 - 10.1111/bju.14361

DO - 10.1111/bju.14361

M3 - Article

C2 - 29699001

SN - 1464-4096

VL - 122

SP - 13

EP - 25

JO - BJU International

JF - BJU International

IS - 1

ER -

National implementation of multi-parametric magnetic resonance imaging for prostate cancer detection – recommendations from a UK consensus meeting

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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