Navigating chemical space for biology and medicine

Christopher Lipinski, Andrew Hopkins

    Research output: Contribution to journalArticlepeer-review

    852 Citations (Scopus)


    Despite over a century of applying organic synthesis to the search for drugs, we are still far from even a cursory examination of the vast number of possible small molecules that could be created. Indeed, a thorough examination of all ‘chemical space’ is practically impossible. Given this, what are the best strategies for identifying small molecules that modulate biological targets? And how might such strategies differ, depending on whether the primary goal is to understand biological systems or to develop potential drugs?
    Original languageEnglish
    Pages (from-to)855-861
    Number of pages7
    Issue number7019
    Publication statusPublished - Dec 2004


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