NCAM Is at the Heart of Reciprocal Regulation of E-Cadherin- and Integrin-Mediated Adhesions via Signaling Modulation

Margaret C. Frame, Gareth J. Inman

    Research output: Contribution to journalEditorial

    21 Citations (Scopus)

    Abstract

    New work by Lehembre et al. in The EMBO Journal reveals that the cell-adhesion molecule, NCAM, is at the heart of crosstalk between E-cadherin loss and reciprocal focal adhesion assembly during the epithelial to mesenchymal transition (EMT). NCAM upregulation induces the formation of novel signaling complexes that correlate with NCAM-dependent focal adhesion assembly, migration, and cancer cell invasion.

    Original languageEnglish
    Pages (from-to)494-496
    Number of pages3
    JournalDevelopmental Cell
    Volume15
    Issue number4
    DOIs
    Publication statusPublished - 14 Oct 2008

    Keywords

    • EPITHELIAL-MESENCHYMAL TRANSITION
    • CELL-ADHESION

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