NCAM Is at the Heart of Reciprocal Regulation of E-Cadherin- and Integrin-Mediated Adhesions via Signaling Modulation

Margaret C. Frame; Gareth J. Inman

doi:10.1016/j.devcel.2008.09.016

NCAM Is at the Heart of Reciprocal Regulation of E-Cadherin- and Integrin-Mediated Adhesions via Signaling Modulation

Margaret C. Frame, Gareth J. Inman

Research output: Contribution to journal › Editorial › peer-review

28 Citations (Scopus)

Abstract

New work by Lehembre et al. in The EMBO Journal reveals that the cell-adhesion molecule, NCAM, is at the heart of crosstalk between E-cadherin loss and reciprocal focal adhesion assembly during the epithelial to mesenchymal transition (EMT). NCAM upregulation induces the formation of novel signaling complexes that correlate with NCAM-dependent focal adhesion assembly, migration, and cancer cell invasion.

Original language	English
Pages (from-to)	494-496
Number of pages	3
Journal	Developmental Cell
Volume	15
Issue number	4
DOIs	https://doi.org/10.1016/j.devcel.2008.09.016
Publication status	Published - 14 Oct 2008

Keywords

EPITHELIAL-MESENCHYMAL TRANSITION
CELL-ADHESION

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.devcel.2008.09.016

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title = "NCAM Is at the Heart of Reciprocal Regulation of E-Cadherin- and Integrin-Mediated Adhesions via Signaling Modulation",

abstract = "New work by Lehembre et al. in The EMBO Journal reveals that the cell-adhesion molecule, NCAM, is at the heart of crosstalk between E-cadherin loss and reciprocal focal adhesion assembly during the epithelial to mesenchymal transition (EMT). NCAM upregulation induces the formation of novel signaling complexes that correlate with NCAM-dependent focal adhesion assembly, migration, and cancer cell invasion.",

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AU - Frame, Margaret C.

AU - Inman, Gareth J.

PY - 2008/10/14

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N2 - New work by Lehembre et al. in The EMBO Journal reveals that the cell-adhesion molecule, NCAM, is at the heart of crosstalk between E-cadherin loss and reciprocal focal adhesion assembly during the epithelial to mesenchymal transition (EMT). NCAM upregulation induces the formation of novel signaling complexes that correlate with NCAM-dependent focal adhesion assembly, migration, and cancer cell invasion.

AB - New work by Lehembre et al. in The EMBO Journal reveals that the cell-adhesion molecule, NCAM, is at the heart of crosstalk between E-cadherin loss and reciprocal focal adhesion assembly during the epithelial to mesenchymal transition (EMT). NCAM upregulation induces the formation of novel signaling complexes that correlate with NCAM-dependent focal adhesion assembly, migration, and cancer cell invasion.

KW - EPITHELIAL-MESENCHYMAL TRANSITION

KW - CELL-ADHESION

U2 - 10.1016/j.devcel.2008.09.016

DO - 10.1016/j.devcel.2008.09.016

M3 - Editorial

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SN - 1534-5807

VL - 15

SP - 494

EP - 496

JO - Developmental Cell

JF - Developmental Cell

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ER -

NCAM Is at the Heart of Reciprocal Regulation of E-Cadherin- and Integrin-Mediated Adhesions via Signaling Modulation

Abstract

Keywords

UN SDGs

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