NCAM Is at the Heart of Reciprocal Regulation of E-Cadherin- and Integrin-Mediated Adhesions via Signaling Modulation

TY - JOUR

T1 - NCAM Is at the Heart of Reciprocal Regulation of E-Cadherin- and Integrin-Mediated Adhesions via Signaling Modulation

AU - Frame, Margaret C.

AU - Inman, Gareth J.

PY - 2008/10/14

Y1 - 2008/10/14

N2 - New work by Lehembre et al. in The EMBO Journal reveals that the cell-adhesion molecule, NCAM, is at the heart of crosstalk between E-cadherin loss and reciprocal focal adhesion assembly during the epithelial to mesenchymal transition (EMT). NCAM upregulation induces the formation of novel signaling complexes that correlate with NCAM-dependent focal adhesion assembly, migration, and cancer cell invasion.

AB - New work by Lehembre et al. in The EMBO Journal reveals that the cell-adhesion molecule, NCAM, is at the heart of crosstalk between E-cadherin loss and reciprocal focal adhesion assembly during the epithelial to mesenchymal transition (EMT). NCAM upregulation induces the formation of novel signaling complexes that correlate with NCAM-dependent focal adhesion assembly, migration, and cancer cell invasion.

KW - EPITHELIAL-MESENCHYMAL TRANSITION

KW - CELL-ADHESION

U2 - 10.1016/j.devcel.2008.09.016

DO - 10.1016/j.devcel.2008.09.016

M3 - Editorial

C2 - 18854134

SN - 1534-5807

VL - 15

SP - 494

EP - 496

JO - Developmental Cell

JF - Developmental Cell

IS - 4

ER -