Near-infrared spectroscopy study of tourniquet-induced forearm ischaemia in patients with coronary artery disease

TY - GEN

T1 - Near-infrared spectroscopy study of tourniquet-induced forearm ischaemia in patients with coronary artery disease

AU - Giardini, Mario E.

AU - Guizzetti, Giovanni Guido

AU - Bavera, Matteo

AU - Lago, Paolo

AU - Corti, Mario

AU - Falcone, Colomba

AU - Pastore, Federico

PY - 2001/6/4

Y1 - 2001/6/4

N2 - Near-Infrared Spectroscopy (NIRS) can be employed to monitor local changes in haemodynamics and oxygenation of human tissues. A preliminary study has been performed in order to evaluate the NIRS transmittance response to induced forearm ischaemia in patients with coronary artery disease (CAD). The population consists in 40 patients with cardiovascular risk factors and angiographically documented CAD, compared to a group of 13 normal subjects. By inflating and subsequently deflating a cuff placed around the patient arm, an ischaemia has been induced and released, and the patients have been observed until recovery of the basal conditions. A custom NIRS spectrometer (IRIS) has been used to collect the backscattered light intensities from the patient forearm throughout the ischaemic and the recovery phase. The time dependence of the near-infrared transmittance on the control group is consistent with the available literature. On the contrary, the magnitude and dynamics of the NIRS signal on the CAD patients show deviations from the documented normal behavior, which can be tentatively attributed to abnormal vessel stiffness. These preliminary results, while validating the performance of the IRIS spectrometer, are strongly conducive towards the applicability of the NIRS technique to ischaemia analysis and to endothelial dysfunction characterization in CAD patients with cardiovascular risk factors.

AB - Near-Infrared Spectroscopy (NIRS) can be employed to monitor local changes in haemodynamics and oxygenation of human tissues. A preliminary study has been performed in order to evaluate the NIRS transmittance response to induced forearm ischaemia in patients with coronary artery disease (CAD). The population consists in 40 patients with cardiovascular risk factors and angiographically documented CAD, compared to a group of 13 normal subjects. By inflating and subsequently deflating a cuff placed around the patient arm, an ischaemia has been induced and released, and the patients have been observed until recovery of the basal conditions. A custom NIRS spectrometer (IRIS) has been used to collect the backscattered light intensities from the patient forearm throughout the ischaemic and the recovery phase. The time dependence of the near-infrared transmittance on the control group is consistent with the available literature. On the contrary, the magnitude and dynamics of the NIRS signal on the CAD patients show deviations from the documented normal behavior, which can be tentatively attributed to abnormal vessel stiffness. These preliminary results, while validating the performance of the IRIS spectrometer, are strongly conducive towards the applicability of the NIRS technique to ischaemia analysis and to endothelial dysfunction characterization in CAD patients with cardiovascular risk factors.

KW - CAD

KW - Cardiovascular risk

KW - Near-infrared spectroscopy

KW - NIRS

UR - https://www.scopus.com/pages/publications/0034866548

U2 - 10.1117/12.427938

DO - 10.1117/12.427938

M3 - Conference contribution

AN - SCOPUS:0034866548

VL - 4254

T3 - Proceedings of SPIE - The International Society for Optical Engineering

SP - 1

EP - 6

BT - Biomedical Diagnostic, Guidance, and Surgical Assist Systems III

A2 - Vo-Dinh, Tuan

A2 - Grundfest, Warren S.

A2 - Benaron, David A.

PB - Society of Photo-optical Instrumentation Engineers

T2 - BiOS 2001 The International Symposium on Biomedical Optics

Y2 - 20 January 2001 through 26 January 2001

ER -