Negative feedback regulation of FGF signaling levels by Pyst1/MKP3 in chick embryos

Maxwell C Eblaghie; J. Simon Lunn; Robin J. Dickinson; Andrea E. Münsterberg; Juan Jose Sanz-Ezquerro; Elizabeth R Farrell; Joanne Mathers; Stephen M Keyse; Kate Storey; Cheryll Tickle

doi:10.1016/S0960-9822(03)00381-6

Negative feedback regulation of FGF signaling levels by Pyst1/MKP3 in chick embryos

Maxwell C Eblaghie, J. Simon Lunn, Robin J. Dickinson, Andrea E. Münsterberg, Juan Jose Sanz-Ezquerro, Elizabeth R Farrell, Joanne Mathers, Stephen M Keyse, Kate Storey, Cheryll Tickle

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153 Citations (Scopus)

Abstract

The importance of endogenous antagonists in intracellular signal transduction pathways is becoming increasingly recognized. There is evidence in cultured mammalian cells that Pyst1/MKP3, a dual specificity protein phosphatase, specifically binds to and inactivates ERK1/2 mitogen-activated protein kinases (MAPKs). High-level Pyst1/Mkp3 expression has recently been found at many sites of known FGF signaling in mouse embryos, but the significance of this association and its function are not known.

Original language	English
Pages (from-to)	1009-18
Number of pages	10
Journal	Current Biology
Volume	13
Issue number	12
DOIs	https://doi.org/10.1016/S0960-9822(03)00381-6
Publication status	Published - Jun 2003

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title = "Negative feedback regulation of FGF signaling levels by Pyst1/MKP3 in chick embryos",

abstract = "The importance of endogenous antagonists in intracellular signal transduction pathways is becoming increasingly recognized. There is evidence in cultured mammalian cells that Pyst1/MKP3, a dual specificity protein phosphatase, specifically binds to and inactivates ERK1/2 mitogen-activated protein kinases (MAPKs). High-level Pyst1/Mkp3 expression has recently been found at many sites of known FGF signaling in mouse embryos, but the significance of this association and its function are not known.",

author = "Eblaghie, {Maxwell C} and Lunn, {J. Simon} and Dickinson, {Robin J.} and M{\"u}nsterberg, {Andrea E.} and Sanz-Ezquerro, {Juan Jose} and Farrell, {Elizabeth R} and Joanne Mathers and Keyse, {Stephen M} and Kate Storey and Cheryll Tickle",

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T1 - Negative feedback regulation of FGF signaling levels by Pyst1/MKP3 in chick embryos

AU - Eblaghie, Maxwell C

AU - Lunn, J. Simon

AU - Dickinson, Robin J.

AU - Münsterberg, Andrea E.

AU - Sanz-Ezquerro, Juan Jose

AU - Farrell, Elizabeth R

AU - Mathers, Joanne

AU - Keyse, Stephen M

AU - Storey, Kate

AU - Tickle, Cheryll

PY - 2003/6

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N2 - The importance of endogenous antagonists in intracellular signal transduction pathways is becoming increasingly recognized. There is evidence in cultured mammalian cells that Pyst1/MKP3, a dual specificity protein phosphatase, specifically binds to and inactivates ERK1/2 mitogen-activated protein kinases (MAPKs). High-level Pyst1/Mkp3 expression has recently been found at many sites of known FGF signaling in mouse embryos, but the significance of this association and its function are not known.

AB - The importance of endogenous antagonists in intracellular signal transduction pathways is becoming increasingly recognized. There is evidence in cultured mammalian cells that Pyst1/MKP3, a dual specificity protein phosphatase, specifically binds to and inactivates ERK1/2 mitogen-activated protein kinases (MAPKs). High-level Pyst1/Mkp3 expression has recently been found at many sites of known FGF signaling in mouse embryos, but the significance of this association and its function are not known.

U2 - 10.1016/S0960-9822(03)00381-6

DO - 10.1016/S0960-9822(03)00381-6

M3 - Article

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SN - 0960-9822

VL - 13

SP - 1009

EP - 1018

JO - Current Biology

JF - Current Biology

IS - 12

ER -

Negative feedback regulation of FGF signaling levels by Pyst1/MKP3 in chick embryos

Abstract

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