Negative feedback regulation of FGF signaling levels by Pyst1/MKP3 in chick embryos

Maxwell C Eblaghie, J. Simon Lunn, Robin J. Dickinson, Andrea E. Münsterberg, Juan Jose Sanz-Ezquerro, Elizabeth R Farrell, Joanne Mathers, Stephen M Keyse, Kate Storey, Cheryll Tickle

    Research output: Contribution to journalArticle

    137 Citations (Scopus)

    Abstract

    The importance of endogenous antagonists in intracellular signal transduction pathways is becoming increasingly recognized. There is evidence in cultured mammalian cells that Pyst1/MKP3, a dual specificity protein phosphatase, specifically binds to and inactivates ERK1/2 mitogen-activated protein kinases (MAPKs). High-level Pyst1/Mkp3 expression has recently been found at many sites of known FGF signaling in mouse embryos, but the significance of this association and its function are not known.
    Original languageEnglish
    Pages (from-to)1009-18
    Number of pages10
    JournalCurrent Biology
    Volume13
    Issue number12
    DOIs
    Publication statusPublished - Jun 2003

    Fingerprint

    Dual-Specificity Phosphatases
    Signal transduction
    Phosphoprotein Phosphatases
    Mitogen-Activated Protein Kinase 1
    Chick Embryo
    mitogen-activated protein kinase
    signal transduction
    antagonists
    Cultured Cells
    Signal Transduction
    embryo (animal)
    Embryonic Structures
    chicks
    Cells
    Association reactions
    Feedback
    mice
    proteins
    cells

    Cite this

    Eblaghie, M. C., Lunn, J. S., Dickinson, R. J., Münsterberg, A. E., Sanz-Ezquerro, J. J., Farrell, E. R., ... Tickle, C. (2003). Negative feedback regulation of FGF signaling levels by Pyst1/MKP3 in chick embryos. Current Biology, 13(12), 1009-18. https://doi.org/10.1016/S0960-9822(03)00381-6
    Eblaghie, Maxwell C ; Lunn, J. Simon ; Dickinson, Robin J. ; Münsterberg, Andrea E. ; Sanz-Ezquerro, Juan Jose ; Farrell, Elizabeth R ; Mathers, Joanne ; Keyse, Stephen M ; Storey, Kate ; Tickle, Cheryll. / Negative feedback regulation of FGF signaling levels by Pyst1/MKP3 in chick embryos. In: Current Biology. 2003 ; Vol. 13, No. 12. pp. 1009-18.
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    abstract = "The importance of endogenous antagonists in intracellular signal transduction pathways is becoming increasingly recognized. There is evidence in cultured mammalian cells that Pyst1/MKP3, a dual specificity protein phosphatase, specifically binds to and inactivates ERK1/2 mitogen-activated protein kinases (MAPKs). High-level Pyst1/Mkp3 expression has recently been found at many sites of known FGF signaling in mouse embryos, but the significance of this association and its function are not known.",
    author = "Eblaghie, {Maxwell C} and Lunn, {J. Simon} and Dickinson, {Robin J.} and M{\"u}nsterberg, {Andrea E.} and Sanz-Ezquerro, {Juan Jose} and Farrell, {Elizabeth R} and Joanne Mathers and Keyse, {Stephen M} and Kate Storey and Cheryll Tickle",
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    Eblaghie, MC, Lunn, JS, Dickinson, RJ, Münsterberg, AE, Sanz-Ezquerro, JJ, Farrell, ER, Mathers, J, Keyse, SM, Storey, K & Tickle, C 2003, 'Negative feedback regulation of FGF signaling levels by Pyst1/MKP3 in chick embryos', Current Biology, vol. 13, no. 12, pp. 1009-18. https://doi.org/10.1016/S0960-9822(03)00381-6

    Negative feedback regulation of FGF signaling levels by Pyst1/MKP3 in chick embryos. / Eblaghie, Maxwell C; Lunn, J. Simon; Dickinson, Robin J.; Münsterberg, Andrea E.; Sanz-Ezquerro, Juan Jose; Farrell, Elizabeth R; Mathers, Joanne; Keyse, Stephen M; Storey, Kate; Tickle, Cheryll.

    In: Current Biology, Vol. 13, No. 12, 06.2003, p. 1009-18.

    Research output: Contribution to journalArticle

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    AU - Lunn, J. Simon

    AU - Dickinson, Robin J.

    AU - Münsterberg, Andrea E.

    AU - Sanz-Ezquerro, Juan Jose

    AU - Farrell, Elizabeth R

    AU - Mathers, Joanne

    AU - Keyse, Stephen M

    AU - Storey, Kate

    AU - Tickle, Cheryll

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    AB - The importance of endogenous antagonists in intracellular signal transduction pathways is becoming increasingly recognized. There is evidence in cultured mammalian cells that Pyst1/MKP3, a dual specificity protein phosphatase, specifically binds to and inactivates ERK1/2 mitogen-activated protein kinases (MAPKs). High-level Pyst1/Mkp3 expression has recently been found at many sites of known FGF signaling in mouse embryos, but the significance of this association and its function are not known.

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    DO - 10.1016/S0960-9822(03)00381-6

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    Eblaghie MC, Lunn JS, Dickinson RJ, Münsterberg AE, Sanz-Ezquerro JJ, Farrell ER et al. Negative feedback regulation of FGF signaling levels by Pyst1/MKP3 in chick embryos. Current Biology. 2003 Jun;13(12):1009-18. https://doi.org/10.1016/S0960-9822(03)00381-6