Negative feedback regulation of FGF signaling levels by Pyst1/MKP3 in chick embryos

TY - JOUR

T1 - Negative feedback regulation of FGF signaling levels by Pyst1/MKP3 in chick embryos

AU - Eblaghie, Maxwell C

AU - Lunn, J. Simon

AU - Dickinson, Robin J.

AU - Münsterberg, Andrea E.

AU - Sanz-Ezquerro, Juan Jose

AU - Farrell, Elizabeth R

AU - Mathers, Joanne

AU - Keyse, Stephen M

AU - Storey, Kate

AU - Tickle, Cheryll

PY - 2003/6

Y1 - 2003/6

N2 - The importance of endogenous antagonists in intracellular signal transduction pathways is becoming increasingly recognized. There is evidence in cultured mammalian cells that Pyst1/MKP3, a dual specificity protein phosphatase, specifically binds to and inactivates ERK1/2 mitogen-activated protein kinases (MAPKs). High-level Pyst1/Mkp3 expression has recently been found at many sites of known FGF signaling in mouse embryos, but the significance of this association and its function are not known.

AB - The importance of endogenous antagonists in intracellular signal transduction pathways is becoming increasingly recognized. There is evidence in cultured mammalian cells that Pyst1/MKP3, a dual specificity protein phosphatase, specifically binds to and inactivates ERK1/2 mitogen-activated protein kinases (MAPKs). High-level Pyst1/Mkp3 expression has recently been found at many sites of known FGF signaling in mouse embryos, but the significance of this association and its function are not known.

U2 - 10.1016/S0960-9822(03)00381-6

DO - 10.1016/S0960-9822(03)00381-6

M3 - Article

C2 - 12814546

SN - 0960-9822

VL - 13

SP - 1009

EP - 1018

JO - Current Biology

JF - Current Biology

IS - 12

ER -