NET formation - mechanisms and how they relate to other cell death pathways

Thibault Rosazza, Jordan Warner, Gabriel Sollberger (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)
34 Downloads (Pure)

Abstract

Cell death is an integral part of both infectious and sterile inflammatory reactions. Many cell death pathways cause the dying cell to lyse, thereby amplifying inflammation. A special form of lytic cell death is the formation of neutrophil extracellular traps (NETs), large structures of chromatin and antimicrobial proteins, which are released by dying neutrophils to capture extracellular pathogens and limit the spread of infections. The molecular mechanisms of NET formation remain incompletely understood. Recent research demonstrated substantial crosstalk between different cell death pathways, most notably between apoptosis, pyroptosis and necroptosis. Here, we review suicidal and vital NET formation and discuss potential crosstalk of their mechanisms of release with other forms of cell death.

Original languageEnglish
Pages (from-to)3334-3350
Number of pages17
JournalFEBS Journal
Volume288
Issue number11
Early online date12 Oct 2020
DOIs
Publication statusPublished - 7 Jun 2021

Keywords

  • Neutrophils
  • NET formation
  • cell death
  • inflammation
  • innate immunity
  • neutrophils

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