Neural differentiation of mouse embryonic stem cells

M. P. Stavridis, A. G. Smith

    Research output: Contribution to journalReview article

    74 Citations (Scopus)

    Abstract

    Pluripotent embryonic stem cells can give rise to neuroectodermal derivatives in culture. This potential could be harnessed to generate neurons and glia for cell-replacement therapies in the central nervous system and for use in drug discovery. However, current methods of neural differentiation are empirical and relatively inefficient. Here, we review these methodologies and present new tools for quantification, analysis and manipulation of embryonic stem cell neural determination.
    Original languageEnglish
    Pages (from-to)45-49
    Number of pages5
    JournalBiochemical Society Transactions
    Volume31
    Issue numberPt 1
    Publication statusPublished - Feb 2003

    Keywords

    • in vitro neurogenesis
    • Neuron
    • Neural progenitor

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