Neuromesodermal progenitors and the making of the spinal cord

Domingos Henrique, Elsa Abranches, Laure Verrier, Kate G. Storey (Lead / Corresponding author)

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    204 Citations (Scopus)
    233 Downloads (Pure)

    Abstract

    Neuromesodermal progenitors (NMps) contribute to both the elongating spinal cord and the adjacent paraxial mesoderm. It has been assumed that these cells arise as a result of patterning of the anterior neural plate. However, as the molecular mechanisms that specify NMps in vivo are uncovered, and as protocols for generating these bipotent cells from mouse and human pluripotent stem cells in vitro are established, the emerging data suggest that this view needs to be revised. Here, we review the characteristics, regulation, in vitro derivation and in vivo induction of NMps. We propose that these cells arise within primitive streak-associated epiblast via a mechanism that is separable from that which establishes neural fate in the anterior epiblast.We thus argue for the existence of two distinct routes for making central nervous system progenitors.

    Original languageEnglish
    Pages (from-to)2864-2875
    Number of pages12
    JournalDevelopment
    Volume142
    Issue number17
    DOIs
    Publication statusPublished - 1 Sept 2015

    ASJC Scopus subject areas

    • Developmental Biology
    • Molecular Biology

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