Neurosurgery for obsessive-compulsive disorder, other anxiety disorders and depressive disorders

David M.B. Christmas, Ian Crombie, Sam Eljamel, Naomi Fineberg, Bob Macvicar, Keith Matthews, Christian Ruck, Cameron Stark

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


This is the protocol for a review and there is no abstract. The objectives are as follows: (1) Primary objectives: 1.1 To determine the efficacy and adverse outcomes of neurosurgical interventions for:(a) Obsessive-compulsive disorder (OCD)(b) Major Depressive Disorder(c) Other Anxiety disorders (Generalised Anxiety Disorder, Panic Disorder and/ or Agoraphobia, Social Phobia/ Social Anxiety Disorder) Each condition will be considered separately. Treatment comparisons will consist of each neurosurgical intervention versus control. The control group is expected to be either waiting list or treatment as usual for ablative neurosurgery, and 'no stimulation' for VNS and DBS. (2) Secondary objectives: 2.1 To establish the relative efficacy of different neurosurgical procedures, attempting to compare directly where possible. Comparisons will not be performed if the data are not sufficient to permit this.2.2 To determine whether different neurosurgical procedures confer differential risks of side effects and adverse outcomes.

Original languageEnglish
Article numberCD005560
JournalCochrane Database of Systematic Reviews
Issue number2
Publication statusPublished - 25 Feb 2014


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