Neurotrophic effects of leptin on cerebellar Purkinje but not granule neurons in vitro

Ceri E. Oldreive, Jenni Harvey, Gayle H. Doherty

    Research output: Contribution to journalArticlepeer-review

    28 Citations (Scopus)

    Abstract

    As recent evidence has revealed a pro-survival role for the anti-obesity hormone leptin in the nervous system, we investigated the generality of this finding on cerebellar Purkinje and granule neurons in vitro. We found that whilst leptin promoted cerebellar Purkinje neuron survival, it had no affect on cerebellar granule cells. In addition, we discovered that leptin promoted both the outgrowth of neurites from cerebellar Purkinje neurons and increased the complexity of the neurite arbor. Thus, leptin has different effects on two neighbouring populations of neurons within the cerebellum implying specificity of its actions in the central nervous system. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)17-21
    Number of pages5
    JournalNeuroscience Letters
    Volume438
    Issue number1
    DOIs
    Publication statusPublished - 2008

    Keywords

    • cell death
    • cerebellum
    • leptin
    • granule
    • neurite
    • Purkinje
    • CELL-DEATH
    • HIPPOCAMPAL-NEURONS
    • EXPRESSION
    • BRAIN
    • HOMOCYSTEINE
    • APOPTOSIS
    • PROTECTS
    • RECEPTOR
    • MICE

    Cite this