Neutrophils may contribute to the morbidity and mortality of claudicants.

TY - JOUR

T1 - Neutrophils may contribute to the morbidity and mortality of claudicants.

AU - Hickman, P

AU - McCollum, Peter T.

AU - Belch, J. J. F.

PY - 1994/6

Y1 - 1994/6

N2 - Peripheral arterial occlusive disease is a common cause of morbidity in middle-aged men; 5 per cent of those aged over 50 years suffer from intermittent claudication. While claudication itself is not fatal, claudicants have a mortality rate approximately three times that of non-claudicating men of the same age, mainly from cardiovascular disease. This review examines the evidence for involvement of the neutrophil in this increased mortality and describes the possible pathogenesis. It also discusses how treatment of claudication may modify neutrophil behaviour, reducing subsequent mortality and morbidity rates.

AB - Peripheral arterial occlusive disease is a common cause of morbidity in middle-aged men; 5 per cent of those aged over 50 years suffer from intermittent claudication. While claudication itself is not fatal, claudicants have a mortality rate approximately three times that of non-claudicating men of the same age, mainly from cardiovascular disease. This review examines the evidence for involvement of the neutrophil in this increased mortality and describes the possible pathogenesis. It also discusses how treatment of claudication may modify neutrophil behaviour, reducing subsequent mortality and morbidity rates.

U2 - 10.1002/bjs.1800810604

DO - 10.1002/bjs.1800810604

M3 - Article

SN - 0007-1323

VL - 81

SP - 790

EP - 798

JO - British Journal of Surgery

JF - British Journal of Surgery

IS - 6

ER -