Research output per year
Research output per year
Understanding Society Scientific Group, Nick Shrine, Anna L. Guyatt, A. Mesut Erzurumluoglu, Victoria E. Jackson, Brian D. Hobbs, Carl A. Melbourne, Chiara Batini, Katherine A. Fawcett, Kijoung Song, Phuwanat Sakornsakolpat, Xingnan Li, Ruth Boxall, Nicola F. Reeve, Ma'en Obeidat, Jing Hua Zhao, Matthias Wielscher, Stefan Weiss, Katherine A. Kentistou, James P. Cook
Research output: Contribution to journal › Article › peer-review
Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, 139 of which are new. In combination, these variants strongly predict COPD in independent populations. Furthermore, the combined effect of these variants showed generalizability across smokers and never smokers, and across ancestral groups. We highlight biological pathways, known and potential drug targets for COPD and, in phenome-wide association studies, autoimmune-related and other pleiotropic effects of lung function-associated variants. This new genetic evidence has potential to improve future preventive and therapeutic strategies for COPD.
Original language | English |
---|---|
Pages (from-to) | 481-493 |
Number of pages | 13 |
Journal | Nature Genetics |
Volume | 51 |
Issue number | 3 |
Early online date | 25 Feb 2019 |
DOIs | |
Publication status | Published - Mar 2019 |
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Person: Academic