New insights into mTOR Signaling: mTORC2 and beyond

Dario R. Alessi; Laura R. Pearce; Juan M. Garcia-Martinez

doi:10.1126/scisignal.267pe27

New insights into mTOR Signaling: mTORC2 and beyond

Dario R. Alessi, Laura R. Pearce, Juan M. Garcia-Martinez

Research output: Contribution to journal › Article › peer-review

169 Citations (Scopus)

Abstract

The mammalian target of rapamycin complex 2 (mTORC2) plays critical roles in regulating cell growth and proliferation. mTORC2 promotes the activation of the serum glucocorticoid-induced protein kinase (SGK). This mTOR complex also promotes the constitutive phosphorylation of proline-directed serine or threonine sites in the turn motif of Akt and protein kinase C isoforms. mTORC2 may control phosphorylation of the turn motif by promoting the activity of a kinase that targets the Ser/Thr-Pro sequence or by inhibiting the activity of a phosphatase.

Original language	English
Article number	pe27
Pages (from-to)	-
Number of pages	4
Journal	Science Signaling
Volume	2
Issue number	67
DOIs	https://doi.org/10.1126/scisignal.267pe27
Publication status	Published - 21 Apr 2009

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New insights into mTOR Signaling: mTORC2 and beyond

Abstract

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