New insights into mTOR Signaling: mTORC2 and beyond

Dario R. Alessi, Laura R. Pearce, Juan M. Garcia-Martinez

    Research output: Contribution to journalArticlepeer-review

    150 Citations (Scopus)

    Abstract

    The mammalian target of rapamycin complex 2 (mTORC2) plays critical roles in regulating cell growth and proliferation. mTORC2 promotes the activation of the serum glucocorticoid-induced protein kinase (SGK). This mTOR complex also promotes the constitutive phosphorylation of proline-directed serine or threonine sites in the turn motif of Akt and protein kinase C isoforms. mTORC2 may control phosphorylation of the turn motif by promoting the activity of a kinase that targets the Ser/Thr-Pro sequence or by inhibiting the activity of a phosphatase.

    Original languageEnglish
    Article numberpe27
    Pages (from-to)-
    Number of pages4
    JournalScience Signaling
    Volume2
    Issue number67
    DOIs
    Publication statusPublished - 21 Apr 2009

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