New insights into mTOR Signaling: mTORC2 and beyond

TY - JOUR

T1 - New insights into mTOR Signaling

T2 - mTORC2 and beyond

AU - Alessi, Dario R.

AU - Pearce, Laura R.

AU - Garcia-Martinez, Juan M.

PY - 2009/4/21

Y1 - 2009/4/21

N2 - The mammalian target of rapamycin complex 2 (mTORC2) plays critical roles in regulating cell growth and proliferation. mTORC2 promotes the activation of the serum glucocorticoid-induced protein kinase (SGK). This mTOR complex also promotes the constitutive phosphorylation of proline-directed serine or threonine sites in the turn motif of Akt and protein kinase C isoforms. mTORC2 may control phosphorylation of the turn motif by promoting the activity of a kinase that targets the Ser/Thr-Pro sequence or by inhibiting the activity of a phosphatase.

AB - The mammalian target of rapamycin complex 2 (mTORC2) plays critical roles in regulating cell growth and proliferation. mTORC2 promotes the activation of the serum glucocorticoid-induced protein kinase (SGK). This mTOR complex also promotes the constitutive phosphorylation of proline-directed serine or threonine sites in the turn motif of Akt and protein kinase C isoforms. mTORC2 may control phosphorylation of the turn motif by promoting the activity of a kinase that targets the Ser/Thr-Pro sequence or by inhibiting the activity of a phosphatase.

U2 - 10.1126/scisignal.267pe27

DO - 10.1126/scisignal.267pe27

M3 - Article

C2 - 19383978

SN - 1937-9145

VL - 2

SP - -

JO - Science Signaling

JF - Science Signaling

IS - 67

M1 - pe27

ER -