New insights into photodynamic therapy treatment through the use of 3D Monte Carlo radiation transfer modelling

C. Louise Campbell, Kenneth Wood, C. Tom A Brown, Harry Moseley

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Photodynamic therapy (PDT) has been theoretically investigated using a Monte Carlo radiation transfer (MCRT) model. By including complex three dimensional (3D) tumour models a more appropriate representation of the treatment was achieved. The 3D clustered tumour model was compared to a smooth model, resulting in a significantly deeper penetration associated with the clustered model. The results from the work presented here indicates that light might penetrate deeper than suggested by 2D or simple layered models.

    Original languageEnglish
    Title of host publicationPhotonic Therapeutics and Diagnostics XII
    EditorsBernard Choi, Nikiforos Kollias, Haishan Zeng, Hyun Wook Kang, Brian J. F. Wong, Justus F. Ilgner, Guillermo J. Tearney, Kenton W. Gregory, Laura Marcu, Melissa C. Skala, Paul J. Campagnola, Andreas Mandelis
    PublisherSPIE-International Society for Optical Engineering
    ISBN (Print)9781628419245
    DOIs
    Publication statusPublished - 29 Feb 2016
    EventSPIE Photonics West 2016: Photonic Therapeutics and Diagnostics XII - Moscone Center, San Francisco, United States
    Duration: 13 Feb 201614 Feb 2016
    http://spie.org/conferences-and-exhibitions/past-conferences-and-exhibitions/photonics-west-2016 (Link to Conference details)

    Publication series

    NameProceedings of SPIE
    Volume9689
    ISSN (Print)1605-7422
    ISSN (Electronic)2410-9045
    NameProgress in Biomedical Optics and Imaging
    Number1
    Volume17

    Conference

    ConferenceSPIE Photonics West 2016
    CountryUnited States
    CitySan Francisco
    Period13/02/1614/02/16
    Internet address

    Keywords

    • daylight PDT
    • fractal model
    • Monte Carlo radiation transfer
    • non-homogeneous tumour model
    • Photodynamic therapy
    • skin optics

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