New insights into photodynamic therapy treatment through the use of 3D Monte Carlo radiation transfer modelling

C. Louise Campbell, Kenneth Wood, C. Tom A Brown, Harry Moseley

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    1 Citation (Scopus)


    Photodynamic therapy (PDT) has been theoretically investigated using a Monte Carlo radiation transfer (MCRT) model. By including complex three dimensional (3D) tumour models a more appropriate representation of the treatment was achieved. The 3D clustered tumour model was compared to a smooth model, resulting in a significantly deeper penetration associated with the clustered model. The results from the work presented here indicates that light might penetrate deeper than suggested by 2D or simple layered models.

    Original languageEnglish
    Title of host publicationPhotonic Therapeutics and Diagnostics XII
    EditorsBernard Choi, Nikiforos Kollias, Haishan Zeng, Hyun Wook Kang, Brian J. F. Wong, Justus F. Ilgner, Guillermo J. Tearney, Kenton W. Gregory, Laura Marcu, Melissa C. Skala, Paul J. Campagnola, Andreas Mandelis
    PublisherSPIE-International Society for Optical Engineering
    ISBN (Print)9781628419245
    Publication statusPublished - 29 Feb 2016
    EventSPIE Photonics West 2016: Photonic Therapeutics and Diagnostics XII - Moscone Center, San Francisco, United States
    Duration: 13 Feb 201614 Feb 2016 (Link to Conference details)

    Publication series

    NameProceedings of SPIE
    ISSN (Print)1605-7422
    ISSN (Electronic)2410-9045
    NameProgress in Biomedical Optics and Imaging


    ConferenceSPIE Photonics West 2016
    Country/TerritoryUnited States
    CitySan Francisco
    Internet address


    • daylight PDT
    • fractal model
    • Monte Carlo radiation transfer
    • non-homogeneous tumour model
    • Photodynamic therapy
    • skin optics

    ASJC Scopus subject areas

    • Atomic and Molecular Physics, and Optics
    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Radiology Nuclear Medicine and imaging


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