New insights into photodynamic therapy treatment through the use of 3D Monte Carlo radiation transfer modelling

C. Louise Campbell; Kenneth Wood; C. Tom A Brown; Harry Moseley

doi:10.1117/12.2212240

New insights into photodynamic therapy treatment through the use of 3D Monte Carlo radiation transfer modelling

C. Louise Campbell, Kenneth Wood, C. Tom A Brown, Harry Moseley

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

Abstract

Photodynamic therapy (PDT) has been theoretically investigated using a Monte Carlo radiation transfer (MCRT) model. By including complex three dimensional (3D) tumour models a more appropriate representation of the treatment was achieved. The 3D clustered tumour model was compared to a smooth model, resulting in a significantly deeper penetration associated with the clustered model. The results from the work presented here indicates that light might penetrate deeper than suggested by 2D or simple layered models.

Original language	English
Title of host publication	Photonic Therapeutics and Diagnostics XII
Editors	Bernard Choi, Nikiforos Kollias, Haishan Zeng, Hyun Wook Kang, Brian J. F. Wong, Justus F. Ilgner, Guillermo J. Tearney, Kenton W. Gregory, Laura Marcu, Melissa C. Skala, Paul J. Campagnola, Andreas Mandelis
Publisher	SPIE-International Society for Optical Engineering
ISBN (Print)	9781628419245
DOIs	https://doi.org/10.1117/12.2212240
Publication status	Published - 29 Feb 2016
Event	SPIE Photonics West 2016: Photonic Therapeutics and Diagnostics XII - Moscone Center, San Francisco, United States Duration: 13 Feb 2016 → 14 Feb 2016 http://spie.org/conferences-and-exhibitions/past-conferences-and-exhibitions/photonics-west-2016 (Link to Conference details)

Publication series

Name	Proceedings of SPIE
Volume	9689
ISSN (Print)	1605-7422
ISSN (Electronic)	2410-9045

Name	Progress in Biomedical Optics and Imaging
Number	1
Volume	17

Conference

Conference	SPIE Photonics West 2016
Country/Territory	United States
City	San Francisco
Period	13/02/16 → 14/02/16
Internet address	http://spie.org/conferences-and-exhibitions/past-conferences-and-exhibitions/photonics-west-2016 (Link to Conference details)

Keywords

daylight PDT
fractal model
Monte Carlo radiation transfer
non-homogeneous tumour model
Photodynamic therapy
skin optics

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Electronic, Optical and Magnetic Materials
Biomaterials
Radiology Nuclear Medicine and imaging

Access to Document

10.1117/12.2212240

Cite this

Campbell, C. L., Wood, K., Brown, C. T. A., & Moseley, H. (2016). New insights into photodynamic therapy treatment through the use of 3D Monte Carlo radiation transfer modelling. In B. Choi, N. Kollias, H. Zeng, H. W. Kang, B. J. F. Wong, J. F. Ilgner, G. J. Tearney, K. W. Gregory, L. Marcu, M. C. Skala, P. J. Campagnola, & A. Mandelis (Eds.), Photonic Therapeutics and Diagnostics XII Article 96890Q (Proceedings of SPIE; Vol. 9689), (Progress in Biomedical Optics and Imaging; Vol. 17, No. 1). SPIE-International Society for Optical Engineering. https://doi.org/10.1117/12.2212240

Campbell, C. Louise ; Wood, Kenneth ; Brown, C. Tom A et al. / New insights into photodynamic therapy treatment through the use of 3D Monte Carlo radiation transfer modelling. Photonic Therapeutics and Diagnostics XII. editor / Bernard Choi ; Nikiforos Kollias ; Haishan Zeng ; Hyun Wook Kang ; Brian J. F. Wong ; Justus F. Ilgner ; Guillermo J. Tearney ; Kenton W. Gregory ; Laura Marcu ; Melissa C. Skala ; Paul J. Campagnola ; Andreas Mandelis. SPIE-International Society for Optical Engineering, 2016. (Proceedings of SPIE). (Progress in Biomedical Optics and Imaging; 1).

@inproceedings{bf031b7f8fb54468aaa40e6fecf03016,

title = "New insights into photodynamic therapy treatment through the use of 3D Monte Carlo radiation transfer modelling",

abstract = "Photodynamic therapy (PDT) has been theoretically investigated using a Monte Carlo radiation transfer (MCRT) model. By including complex three dimensional (3D) tumour models a more appropriate representation of the treatment was achieved. The 3D clustered tumour model was compared to a smooth model, resulting in a significantly deeper penetration associated with the clustered model. The results from the work presented here indicates that light might penetrate deeper than suggested by 2D or simple layered models.",

keywords = "daylight PDT, fractal model, Monte Carlo radiation transfer, non-homogeneous tumour model, Photodynamic therapy, skin optics",

author = "Campbell, {C. Louise} and Kenneth Wood and Brown, {C. Tom A} and Harry Moseley",

year = "2016",

month = feb,

day = "29",

doi = "10.1117/12.2212240",

language = "English",

isbn = "9781628419245",

series = "Proceedings of SPIE",

publisher = "SPIE-International Society for Optical Engineering",

editor = "Choi, {Bernard } and Kollias, {Nikiforos } and Zeng, {Haishan } and Kang, {Hyun Wook } and Wong, {Brian J. F. } and Ilgner, {Justus F. } and Tearney, {Guillermo J. } and Gregory, {Kenton W. } and Marcu, {Laura } and Skala, {Melissa C. } and Campagnola, {Paul J. } and Mandelis, {Andreas }",

booktitle = "Photonic Therapeutics and Diagnostics XII",

note = "SPIE Photonics West 2016 : Photonic Therapeutics and Diagnostics XII ; Conference date: 13-02-2016 Through 14-02-2016",

url = "http://spie.org/conferences-and-exhibitions/past-conferences-and-exhibitions/photonics-west-2016",

}

Campbell, CL, Wood, K, Brown, CTA & Moseley, H 2016, New insights into photodynamic therapy treatment through the use of 3D Monte Carlo radiation transfer modelling. in B Choi, N Kollias, H Zeng, HW Kang, BJF Wong, JF Ilgner, GJ Tearney, KW Gregory, L Marcu, MC Skala, PJ Campagnola & A Mandelis (eds), Photonic Therapeutics and Diagnostics XII., 96890Q, Proceedings of SPIE, vol. 9689, Progress in Biomedical Optics and Imaging, no. 1, vol. 17, SPIE-International Society for Optical Engineering, SPIE Photonics West 2016, San Francisco, United States, 13/02/16. https://doi.org/10.1117/12.2212240

New insights into photodynamic therapy treatment through the use of 3D Monte Carlo radiation transfer modelling. / Campbell, C. Louise; Wood, Kenneth; Brown, C. Tom A et al.
Photonic Therapeutics and Diagnostics XII. ed. / Bernard Choi; Nikiforos Kollias; Haishan Zeng; Hyun Wook Kang; Brian J. F. Wong; Justus F. Ilgner; Guillermo J. Tearney; Kenton W. Gregory; Laura Marcu; Melissa C. Skala; Paul J. Campagnola; Andreas Mandelis. SPIE-International Society for Optical Engineering, 2016. 96890Q (Proceedings of SPIE; Vol. 9689), (Progress in Biomedical Optics and Imaging; Vol. 17, No. 1).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - New insights into photodynamic therapy treatment through the use of 3D Monte Carlo radiation transfer modelling

AU - Campbell, C. Louise

AU - Wood, Kenneth

AU - Brown, C. Tom A

AU - Moseley, Harry

PY - 2016/2/29

Y1 - 2016/2/29

N2 - Photodynamic therapy (PDT) has been theoretically investigated using a Monte Carlo radiation transfer (MCRT) model. By including complex three dimensional (3D) tumour models a more appropriate representation of the treatment was achieved. The 3D clustered tumour model was compared to a smooth model, resulting in a significantly deeper penetration associated with the clustered model. The results from the work presented here indicates that light might penetrate deeper than suggested by 2D or simple layered models.

AB - Photodynamic therapy (PDT) has been theoretically investigated using a Monte Carlo radiation transfer (MCRT) model. By including complex three dimensional (3D) tumour models a more appropriate representation of the treatment was achieved. The 3D clustered tumour model was compared to a smooth model, resulting in a significantly deeper penetration associated with the clustered model. The results from the work presented here indicates that light might penetrate deeper than suggested by 2D or simple layered models.

KW - daylight PDT

KW - fractal model

KW - Monte Carlo radiation transfer

KW - non-homogeneous tumour model

KW - Photodynamic therapy

KW - skin optics

UR - http://www.scopus.com/inward/record.url?scp=84973369413&partnerID=8YFLogxK

U2 - 10.1117/12.2212240

DO - 10.1117/12.2212240

M3 - Conference contribution

AN - SCOPUS:84973369413

SN - 9781628419245

T3 - Proceedings of SPIE

BT - Photonic Therapeutics and Diagnostics XII

A2 - Choi, Bernard

A2 - Kollias, Nikiforos

A2 - Zeng, Haishan

A2 - Kang, Hyun Wook

A2 - Wong, Brian J. F.

A2 - Ilgner, Justus F.

A2 - Tearney, Guillermo J.

A2 - Gregory, Kenton W.

A2 - Marcu, Laura

A2 - Skala, Melissa C.

A2 - Campagnola, Paul J.

A2 - Mandelis, Andreas

PB - SPIE-International Society for Optical Engineering

T2 - SPIE Photonics West 2016

Y2 - 13 February 2016 through 14 February 2016

ER -

Campbell CL, Wood K, Brown CTA, Moseley H. New insights into photodynamic therapy treatment through the use of 3D Monte Carlo radiation transfer modelling. In Choi B, Kollias N, Zeng H, Kang HW, Wong BJF, Ilgner JF, Tearney GJ, Gregory KW, Marcu L, Skala MC, Campagnola PJ, Mandelis A, editors, Photonic Therapeutics and Diagnostics XII. SPIE-International Society for Optical Engineering. 2016. 96890Q. (Proceedings of SPIE). (Progress in Biomedical Optics and Imaging; 1). doi: 10.1117/12.2212240

New insights into photodynamic therapy treatment through the use of 3D Monte Carlo radiation transfer modelling

Abstract

Publication series

Conference

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this