New insights into the regulation and function of serine/threonine kinases in T lymphocytes

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    Abstract

    The development of T lymphocytes in the thymus and the function of mature T cells in adaptive immune responses are choreographed by antigen receptors, costimulatory molecules, adhesion molecules, cytokines, and chemokines. These extrinsic stimuli are coupled to a diverse network of signal transduction pathways that control the transcriptional and metabolic programs that determine T-cell function. At the core of T-lymphocyte signal transduction is the regulated metabolism of inositol phospholipids and the production of two key lipid second messengers: polyunsaturated diacylglycerols (DAGs) and phosphatidylinositol (3-5) triphosphate [PI-(3-5)-P-3]. The object of the present review is to discuss facts, controversies, and unresolved issues about DAG and PI-(3,4,5)-P-3 production in T lymphocytes and to discuss some of the serine/threonine kinases that control unique aspects of T-lymphocyte biology and coordinate T-cell participation in adaptive immune responses.

    Original languageEnglish
    Pages (from-to)241-252
    Number of pages12
    JournalImmunological Reviews
    Volume228
    Issue number1
    DOIs
    Publication statusPublished - Mar 2009

    Keywords

    • Serine/threonine kinase
    • Diacylglycerol
    • PI-(3,4,5)-P-3
    • T lymphocyte
    • PI3-kinase
    • Signal transduction
    • In vivo role
    • 3-phosphoinositide-dependent protein kinase
    • Cell receptor microclusters
    • Kappa-B activation
    • PKC-theta
    • C-theta
    • Immunological synapse
    • L-selectin
    • Phosphatidylinositol-3-OH kinase
    • Histone deacetylases

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