New mechanical recanalization devices - the future in pediatric stroke treatment

Iris Quasar Grunwald, Silke Walter, Mohammed Ghiath Shamdeen, Anna Dautermann, Christian Roth, Anton Haass, Linet Jenifa Bolar, Wolfgang Reith, Anna Luisa Kühn, Panagiotis Papanagiotou

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)


Objective: To evaluate the recanalization rate and clinical outcome in children with acute ischemic stroke following treatment with innovative mechanical thrombectomy devices.

Patients and methods: Three subjects aged 7-16 years presenting with acute cerebral vascular occlusions (thrombolysis in myocardial infarction [TIMI] 0) were treated with either the Penumbra System, operating on an aspiration platform, or the Phenox clot retriever device, a flexible wire compound with perpendicularly-oriented polyamid microfilaments. Target vessels were the internal carotid artery, the middle cerebral artery and the basilar artery.

Results: Successful recanalization (TIMI 3) was attained in all cases. No device-related complications or intracranial hemorrhage occurred. Follow up was conducted for up to 30 days. A 10- to 26-point improvement in the National Institutes of Health Stroke Scale (NIHSS) score was achieved.

Conclusions: Mechanical thrombectomy devices possess a dual advantage whereby they can achieve instant recanalization as well as minimize the number of bleeds that customarily accompany intravenous and intra-arterial therapy. These new devices could contribute greatly to treatment decisions in a field not yet clearly defined by current guidelines.
Original languageEnglish
Pages (from-to)63-66
Number of pages4
JournalJournal of Invasive Cardiology
Issue number2
Publication statusPublished - Feb 2010


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