TY - JOUR
T1 - New vistas for treatment of obesity and diabetes?
T2 - Endocannabinoid signalling and metabolism in the modulation of energy balance
AU - Lipina, C.
AU - Rastedt, W.
AU - Irving, A.J.
AU - Hundal, H.S.
N1 - Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012/8/1
Y1 - 2012/8/1
N2 - Growing evidence suggests that pathological overactivation of the endocannabinoid system (ECS) is associated with dyslipidemia, obesity and diabetes. Indeed, this signalling system acting through cannabinoid receptors has been shown to function both centrally and peripherally to regulate feeding behaviour as well as energy expenditure and metabolism. Consequently, modulation of these receptors can promote significant alterations in body weight and associated metabolic profile. Importantly, blocking cannabinoid receptor type 1 function has been found to prevent obesity and metabolic dysfunction in various murine models and in humans. Here we provide a detailed account of the known physiological role of the ECS in energy balance, and explore how recent studies have delivered novel insights into the potential targeting of this system as a therapeutic means for treating obesity and related metabolic disorders. The endocannabinoid system (ECS) plays an important role in the regulation of energy metabolism. Its pathological overactivation seems to be associated with dyslipidemia, obesity and diabetes. Targeting the ECS may therefore provide a therapeutic means for treating obesity and related metabolic disorders.
AB - Growing evidence suggests that pathological overactivation of the endocannabinoid system (ECS) is associated with dyslipidemia, obesity and diabetes. Indeed, this signalling system acting through cannabinoid receptors has been shown to function both centrally and peripherally to regulate feeding behaviour as well as energy expenditure and metabolism. Consequently, modulation of these receptors can promote significant alterations in body weight and associated metabolic profile. Importantly, blocking cannabinoid receptor type 1 function has been found to prevent obesity and metabolic dysfunction in various murine models and in humans. Here we provide a detailed account of the known physiological role of the ECS in energy balance, and explore how recent studies have delivered novel insights into the potential targeting of this system as a therapeutic means for treating obesity and related metabolic disorders. The endocannabinoid system (ECS) plays an important role in the regulation of energy metabolism. Its pathological overactivation seems to be associated with dyslipidemia, obesity and diabetes. Targeting the ECS may therefore provide a therapeutic means for treating obesity and related metabolic disorders.
UR - http://www.scopus.com/inward/record.url?scp=84863880828&partnerID=8YFLogxK
U2 - 10.1002/bies.201200031
DO - 10.1002/bies.201200031
M3 - Article
C2 - 22674489
AN - SCOPUS:84863880828
SN - 0265-9247
VL - 34
SP - 681
EP - 691
JO - BioEssays
JF - BioEssays
IS - 8
ER -