NF-κB and HIF crosstalk in immune responses

Laura D'Ignazio, Daniel Bandarra, Sonia Rocha (Lead / Corresponding author)

    Research output: Contribution to journalArticlepeer-review

    247 Citations (Scopus)
    183 Downloads (Pure)

    Abstract

    Hypoxia and inflammation have been associated to a number of pathological conditions, in particular inflammatory diseases. While hypoxia is mainly associated with the activation of Hypoxia-Inducible Factors (HIFs), inflammation activates the family of transcription factor called NF-κB. An extensive crosstalk between these two main molecular players involved in hypoxia and inflammation has been demonstrated. This crosstalk includes common activating stimuli, shared regulators and targets. In this review, we discuss the current understanding of the role of NF-κB and HIF in the context of the immune response. We review the crosstalk between HIF and NF-κB in the control of the immune response in different immune cell types including macrophages, neutrophils and B and T cells. Furthermore the importance of the molecular crosstalk between HIF and NF-κB for a variety of medical conditions will be discussed. This article is protected by copyright. All rights reserved.

    Original languageEnglish
    Pages (from-to)413-424
    Number of pages12
    JournalFEBS Journal
    Volume283
    Issue number3
    Early online date24 Nov 2015
    DOIs
    Publication statusPublished - Feb 2016

    Keywords

    • B cells
    • HIF
    • hypoxia
    • IKK
    • immune response
    • inflammation
    • macrophages
    • neutrophils
    • NF-κb
    • T cells

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