Nickel in Microbial Physiology - From Single Proteins to Complex Trafficking Systems: Nickel Import/Export

Agnes Rodrigue, Marta Albareda, Marie Andrée Mandrand-Berthelot, Jose Palacios

    Research output: Chapter in Book/Report/Conference proceedingChapter

    1 Citation (Scopus)

    Abstract

    In response to the low nickel availability in most natural environments, bacteria have developed high-affinity transporters to meet cell needs for the synthesis of nickel-containing enzymes. Two main categories of such importers are known: single polypeptide permeases and multicomponent members of the ATP-binding cassette (ABC) family. In addition, bacteria possess different kinds of nickel efflux systems to regulate nickel homeostasis and avoid toxic buildup of nickel concentration in the cell. In this chapter we review the recent advances concerning nickel import/export mechanisms that allow bacteria to fulfill metalloenzyme biosynthesis while circumventing the toxicity of this element.

    Original languageEnglish
    Title of host publicationThe Biological Chemistry of Nickel
    Subtitle of host publicationBiochemistry
    EditorsDeborah Zamble, Magdalena Rowinska-Zyrek, Henryk Kozlowski
    PublisherRoyal Society of Chemistry
    Pages237-258
    Number of pages22
    Volume2017-January
    Edition10
    ISBN (Electronic)97811788011235
    ISBN (Print)9781782624981
    DOIs
    Publication statusPublished - 4 Apr 2017

    Publication series

    NameRSC Metallobiology
    Number10
    Volume2017-January
    ISSN (Print)2045547X

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    Rodrigue, A., Albareda, M., Mandrand-Berthelot, M. A., & Palacios, J. (2017). Nickel in Microbial Physiology - From Single Proteins to Complex Trafficking Systems: Nickel Import/Export. In D. Zamble, M. Rowinska-Zyrek, & H. Kozlowski (Eds.), The Biological Chemistry of Nickel: Biochemistry (10 ed., Vol. 2017-January, pp. 237-258). (RSC Metallobiology; Vol. 2017-January, No. 10). Royal Society of Chemistry. https://doi.org/10.1039/9781788010580-00237