Nicotine

D. J. K. Balfour; C. S. Birch

doi:10.1016/B978-008045046-9.01131-1

Nicotine

D. J. K. Balfour, C. S. Birch

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Abstract

This article summarizes evidence that the psychomotor stimulant and addictive properties of nicotine are mediated by stimulation of nicotinic acetylcholine receptors located on or close to the dopamine (DA)-secreting neurons which innervate the nucleus accumbens. This stimulation increases DA overflow within the core and shell subdivisions of the accumbens. The shell is thought to mediate the reinforcing properties of the drug itself, whereas the core is thought to mediate the effects which conditioned stimuli contribute to nicotine-seeking behavior. The article also considers the putative role that the anti-anxiety and antidepressant properties of nicotine may play in the development of addiction.

Original language	English
Title of host publication	Encyclopedia of neuroscience
Editors	Larry R. Squire
Place of Publication	London
Publisher	Academic Press
Pages	1121-1127
Number of pages	7
ISBN (Print)	9780080450469
DOIs	https://doi.org/10.1016/B978-008045046-9.01131-1
Publication status	Published - 2010

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AB - This article summarizes evidence that the psychomotor stimulant and addictive properties of nicotine are mediated by stimulation of nicotinic acetylcholine receptors located on or close to the dopamine (DA)-secreting neurons which innervate the nucleus accumbens. This stimulation increases DA overflow within the core and shell subdivisions of the accumbens. The shell is thought to mediate the reinforcing properties of the drug itself, whereas the core is thought to mediate the effects which conditioned stimuli contribute to nicotine-seeking behavior. The article also considers the putative role that the anti-anxiety and antidepressant properties of nicotine may play in the development of addiction.

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BT - Encyclopedia of neuroscience

A2 - Squire, Larry R.

PB - Academic Press

CY - London

ER -

Nicotine

Abstract

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